DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	183/524 - (34%)
Similarity:	290/524 - (55%)	Gaps:	46/524 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse    10 ETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGLWK---FDMEC--YKKYG 69
            |.:.|.||:..|.||:.:..::.||.:||...||:.:.|.:...:  |.|   ||:.|  |.|.|
  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMF--LRKRAMFDIVCDLYTKGG 66

Mouse    70 --KTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRR-------DFGP---VGIMSKAISISK 122
              |.:|:|:.:.|||.|.||:.||.:.:|: |..|.|.|       |..|   ..:...::...:
  Fly    67 SKKFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMR 130

Mouse   123 DDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKK--GKPVTMKDVLGAYSMDVIT 185
            |..||..|:.|||.||..|:::||.::.|.....|..|:|...:  ...:.|||....::.|||.
  Fly   131 DARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIA 195

Mouse   186 STSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFK 250
            ||:||:.|:|..:.|:.|.:..|||..|.|...:.|  :||..|..:.::|.:.:|.:.|.::|.
  Fly   196 STAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKF--MLFFALKGLNKILKVELFDRKSTQYFV 258

Mouse   251 KFV-DRMKESRLDSKQKH---RVDFLQLMMNSH---NNSKDKVSH-KALSDMEITAQSIIFIFAG 307
            :.| |.||     .:|:|   |.|.:.::|.:.   ...|.|.|. :..||.:|.||..:|.|||
  Fly   259 RLVLDAMK-----YRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAG 318

Mouse   308 YETTSSTLSFTLHSLATHPDIQKKLQDE---IDEALPNKAPPTYDTVMEMEYLDMVLNETLRLYP 369
            :||::..:.||.|.|..:.|:|::|.:|   :|:.|..| ..||:.:|.|:|||.|:||.||.:|
  Fly   319 FETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRKWP 382

Mouse   370 IANRLERVCKKDV--ELNG--VYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDP 430
            .|..::|.|.||:  :::|  |.:.||..:.:|:...|.||:::..|.:|.|||||.|||.||.|
  Fly   383 AAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQP 447

Mouse   431 YVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGL-LQPEKPIVLKV 494
            :.|.|||.|.|||:|.||||:..|..:..:::::.|.|.|::.|||:|...|. |.|:....:|:
  Fly   448 FTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKL 512

Mouse   495 VPRD 498
            |.|:
  Fly   513 VQRN 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	169/489 (35%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	169/484 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	1	0.950	-	0	Normalized mean entropy	S3417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.750