DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp9c1

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	162/525 - (30%)
Similarity:	278/525 - (52%)	Gaps:	53/525 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTV--------LNYYKGLWKFDMECY 65
            :|..:.:|...:|||::.......|.|:|:...||:|.||.:        .:|.|  ...|:...
  Fly     4 VELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIK--HSIDLHLR 66

Mouse    66 KKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRR-----DFGPVGIMSKAISISKDDE 125
            .|..|.:|:|:.:.||..::|||.|:.|.:|. |..|||.|     .|....::||::...:|..
  Fly    67 LKQHKVYGVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSLRDRR 130

Mouse   126 WKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKG-KPVTMKDVLGAYSMDVITSTSF 189
            ||:.|:.|:|||||.|:::||.:|.......|.:::::...| ..:.:||....|:.|||.:.:|
  Fly   131 WKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAAF 195

Mouse   190 GVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVD 254
            |:.|:|..:|.:.|....:::..|.|:..|  .|:|:..:..:.:.|.:.:...:::::|||.|.
  Fly   196 GIQVNSFKDPNNEFFSIGQRISEFTFWGGL--KVMLYILMPKLMKALRVPVMDMNNVDYFKKLVF 258

Mouse   255 RMKESRLDSKQKH--RVDFLQLMMNSHNNSKDKVSHKA----------LSDMEITAQSIIFIFAG 307
            ...:.|   |::.  |.|.:.|:|.:....|.:....|          .:|.::.||.::|..||
  Fly   259 GAMKYR---KEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAG 320

Mouse   308 YETTSSTLSFTLHSLATHPDIQKKLQDEI---DEALPNKAPPTYDTVMEMEYLDMVLNETLRLYP 369
            :||.::.||||.:.|..:|::|:||..||   .|.|..| |..|||:|.|:||:.|::|:||.:|
  Fly   321 FETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEK-PLDYDTLMGMKYLNCVVSESLRKWP 384

Mouse   370 IANRLERVCKKDVELNG------VYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSI 428
            .|..::|:|..|.:|..      |.:.:...|.|...||||||.::.|||:|:||||.:|:|..|
  Fly   385 PAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEI 449

Mouse   429 DPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLK 493
            ..:.|||||.|.|:|:|.|.|||.:|..:.:::..:..:|...|...:..|..|         .:
  Fly   450 RQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISG---------FR 505

Mouse   494 VVPRD 498
            ::||:
  Fly   506 LLPRE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	152/489 (31%)
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	154/492 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800