DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp6a21

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	149/497 - (29%)
Similarity:	250/497 - (50%)	Gaps:	34/497 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTV-----LNYYKGLWKFDMECYKKY 68
            |.|.:|..:..:|:....|.:|  ::..|||..:|...:|::     ...:..:|......::..
  Fly     7 LLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGS 69

Mouse    69 GKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDF-----GPVGIMSKAISISKDDEWKR 128
            |...|.:..:.|.:.|.:....|.:|:|| |:.||:|..|     .|   :|..:.:....:|:.
  Fly    70 GPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDDP---LSGQLFLLDGQKWRT 130

Mouse   129 YRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNV 193
            .|..||.||||||:|.|||.:.:..:.......|...|...|.::::|..::.|||.:.:||:..
  Fly   131 MRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCAFGIEC 195

Mouse   194 DSLNNPEDPFVEKAKKLLRFDFFDPLLFSVV-LFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMK 257
            .||.:|:..|.|..::.|......|:....| .||.|.   ..|::.|..:....||.:.|....
  Fly   196 SSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMTAEPIERFFMRIVRETV 257

Mouse   258 ESRLDSKQKHRVDFLQLMMNSHN------NSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLS 316
            ..| :.....|.||:..:::..|      .|.:.|:   |:..||.||:.:|..||:||:|:|:.
  Fly   258 AFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN---LTIEEIAAQAFVFFAAGFETSSTTMG 318

Mouse   317 FTLHSLATHPDIQKKLQDEIDEALPN-KAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKK 380
            |.|:.||.:.|||.:::.|..|.:.. .....|:::.::.|||.|::||||||.:...|.|.|.:
  Fly   319 FALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLE 383

Mouse   381 DVELNG---VYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRN 442
            |.|:.|   ..|.||..|:||..|:|.|.:.::.|..|.|:.||.|.....|...:||||:||||
  Fly   384 DYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRN 448

Mouse   443 CLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLL 484
            |:||||..|..::.|..::::|.|..|::|.||:..:::..|
  Fly   449 CIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	141/467 (30%)
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	141/467 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720