DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	167/515 - (32%)
Similarity:	268/515 - (52%)	Gaps:	54/515 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 VLLAISLVLLYRYGTRKH-ELFKKQGIPGPKP-LPF------LGTVLNYYKGLWKFDMECYKKY- 68
            ::|.|.::....:...:| ..:|::|||..:| :|:      :.||  ::..::|   ..|.|.
  Fly     5 IVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTV--HFADIFK---RTYNKLR 64

Mouse    69 GKTWGLFDG----QTPLLAVTDPETIKNVLVKECF------SVFTNRRDFGPVGIMSKAISISKD 123
            .||.|.|.|    ...::.|||.:..|.||::| |      .||.|.|| .|  :.:..::|. .
  Fly    65 NKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIRE-FDKFHDRGVFHNERD-DP--LSANLVNID-G 124

Mouse   124 DEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAK-KGKPVTMKDVLGAYSMDVITST 187
            .:||..|..|:|||||||:|.|||.|...||.|::...:.|. ....:.:.:|:..::.|||.|.
  Fly   125 QKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSC 189

Mouse   188 SFGVNVDSLNNPEDPFVEKAKKLL----RFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEF 248
            :||::..||::|:..||:.....:    .....|.|||..   |.|.....|       |.:::.
  Fly   190 AFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGA---PELAAKLRM-------KATVQE 244

Mouse   249 FKKFVDRMKESRLDSKQKHRV---DFLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAGYET 310
            .:.|...:....:|.:.|:.|   ||:.:::.......:......|:..||.||:.||..||:||
  Fly   245 VEDFYMNIIRDTVDYRVKNNVKRHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFET 309

Mouse   311 TSSTLSFTLHSLATHPDIQKKLQDEIDEAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRL 374
            :|:|:.|.|:.||.|.|||.||:.||:..| .:.....||::.||.||:.|::||:|..|:...|
  Fly   310 SSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHL 374

Mouse   375 ERVCKKDVE-LNGVY-IPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFG 437
            .||..:..: .|..| |.||:.|::|:.|:||||:.:.|||:|.||||.::.........:||||
  Fly   375 IRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLPFG 439

Mouse   438 NGPRNCLGMRFALMNMKLALTKIMQNFSFQ--PCKETQIPLKLSRQG-LLQPEKPIVLKV 494
            :|||||:|:||..|.:.:.:..::.||.|:  |.| |.:||:..... ||..:..|.|||
  Fly   440 DGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK-TVVPLEYRTDDFLLSSKGGIHLKV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	159/486 (33%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	158/484 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720