DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	162/514 - (31%)
Similarity:	266/514 - (51%)	Gaps:	50/514 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 VLLAISLV----LLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNY-----YKGLWKFDMECYKKY 68
            |||||.:|    ||.::....| .::...||..:|...:|::...     :..:|   |:.|.|:
  Fly     6 VLLAIVVVLVGYLLLKWRRALH-YWQNLDIPCEEPHILMGSLTGVQTSRSFSAIW---MDYYNKF 66

Mouse    69 GKTWGLFDG----QTPLLAVTDPETIKNVLVKECFSVFTNR-----RDFGPVGIMSKAISISKDD 124
            ..| |.|.|    |.|.:.|.|....|.:|:|| |:.||:|     .:..|   :|..:.:....
  Fly    67 RGT-GPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDP---LSGQLFLLDGQ 126

Mouse   125 EWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSF 189
            :||..|:.||.||||||:|.|||.:.:.|...::...|..:|...|.::|:|..::.|||.:.:|
  Fly   127 KWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAF 191

Mouse   190 GVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVD 254
            |:...||.:||..|....::.:......|:..:.:      ..::.|...:..|.::|..:.|..
  Fly   192 GIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFI------NSFQNLARRLHMKITLEEAEHFFL 250

Mouse   255 RMKESRLDSKQKHRV---DFLQLMMNSHNN------SKDKVSHKALSDMEITAQSIIFIFAGYET 310
            |:....:..::|:.:   ||:..:::..|:      |.:.|:   |:..|:.||:.:|..||:||
  Fly   251 RIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVN---LTIEEMAAQAFVFFGAGFET 312

Mouse   311 TSSTLSFTLHSLATHPDIQKKLQDEIDEALPN-KAPPTYDTVMEMEYLDMVLNETLRLYPIANRL 374
            :|:|:.|.|:.||.|.|||.:::.|..|.:.. ....||:::.:|.|||.|::||||||.:...|
  Fly   313 SSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVL 377

Mouse   375 ERVCKKDVELNG---VYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPF 436
            .|.|.:|.|:.|   ..|.||..|:||..|:|.|.:.::.|..|.|:.||.|.....|...:|||
  Fly   378 NRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPF 442

Mouse   437 GNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQG-LLQPEKPIVLKV 494
            |:|||||:||||..|..:..|..::..|.|..|::|.||:..|::. |:..|..|.|||
  Fly   443 GDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	150/482 (31%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	149/480 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720