DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	173/529 - (32%)
Similarity:	273/529 - (51%)	Gaps:	67/529 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGLWK------FDMECYKK 67
            |.|..|:.:.|.|.|....:....:|::|:|...|||.:|.:    :|:.|      .:...|||
  Fly     2 LFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNM----RGIVKKYHFRDINQRIYKK 62

Mouse    68 YGKTWGLFDGQTPLLA----------VTDPETIKNVLVKECFS------VFTNRRDFGPVGIMSK 116
                   |.||.|:..          :||.:.||.|::|: ||      .|||.||....|
  Fly    63 -------FKGQGPIAGMYMFFKRTALITDLDFIKQVMIKD-FSYFQDRGAFTNPRDDPLTG---- 115

Mouse   117 AISISKDDEWKRYRALLSPTFTSGKLKEMFPVIE----QYGDILVKYLRQ-KAKKGKPVTMKDVL 176
            .:...:.:||:..|..|:|.|||||:|:|..||.    :.||.:.|.::: |.::|. |.:||:.
  Fly   116 HLFALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGN-VEIKDLC 179

Mouse   177 GAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFL---TPVYEMLNI 238
            ..::.|||.|.:||:..:||.:|...|.:|.:::     |.....|.::..|:   ..:...|.|
  Fly   180 ARFTTDVIGSCAFGLECNSLQDPSAEFRQKGREI-----FTRRRHSTLVQSFIFTNARLARKLRI 239

Mouse   239 CMFPKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKD--------KVSHKALSDME 295
            .:.|.|..:||...|....:.||.:..| |.||::.|:......::        .:|| .|:..:
  Fly   240 KVLPDDLTQFFMSTVKNTVDYRLKNGIK-RNDFIEQMIELRAEDQEAAKKGQGIDLSH-GLTLEQ 302

Mouse   296 ITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPN--KAPPTYDTVMEMEYLD 358
            :.||:.:|..||:||:|||:|..|:.||..||||::|::||:..|.|  .....||.:.:|.|||
  Fly   303 MAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLD 367

Mouse   359 MVLNETLRLYPIANRLERVCKKDVEL--NGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFS 421
            .||:||||.:|:...|.|...||.::  :.:.:.||...:||.:.:||||:.:.|||:|.|.||.
  Fly   368 QVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFD 432

Mouse   422 KENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQG-LLQ 485
            .|...:..|..|||||:|||||:|:||..:..|:.|..:::.|.|.....|.:||..|::. ||.
  Fly   433 PEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLT 497

Mouse   486 PEKPIVLKV 494
            ....|.|||
  Fly   498 TNDGIYLKV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	163/497 (33%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	163/497 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850