DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	121/514 - (23%)
Similarity:	242/514 - (47%)	Gaps:	75/514 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 WVLLAISL---VLLYRY----GTRKHELFKKQGIPGPKPLPFLGT----------VLNYYKGLWK 59
            |.:|.|.|   :||..|    ..|:..:..|  ..||:.||.:|.          :|:.....|
  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNK--FNGPRGLPLMGNAHQMGKNPSEILDTVFSWW- 63

Mouse    60 FDMECYKKYGK-TWGLFDGQTPLLAVTDPETIKNVLVKECF----SVFTNRRDFGPVGIMSKAIS 119
                  .:||| .:..:.|....:.||..:.::.:|..:..    .::.....:..:|:::
  Fly    64 ------HQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLT---- 118

Mouse   120 ISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVI 184
             |...:|.::|.:::|.|....|::...|:.:.....:|:|:..|........::.....::|||
  Fly   119 -STGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI 182

Mouse   185 TSTSFGVNVDSLNNPEDPFVEKAKKL---LRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSI 246
            ..|:.||:::::.|.....|:..|.:   :....|.||..:.:|:. |.|.|...:      .::
  Fly   183 CDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYR-LAPDYPAYS------RTL 240

Mouse   247 EFFKKFVDRMKESRLDSKQ-------------KHRVDFLQLMMNSHNNSKDKVSHKALSDMEITA 298
            :..:.|.:.:...|:::.:             :.::.||..:::|      .:..:.|:..|:..
  Fly   241 KTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSS------TIDGRPLNSKELYE 299

Mouse   299 QSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNK---APPTYDTVMEMEYLDMV 360
            :...|:|.|::||:|.:||.::.|:.|.|.|:||..|..|.:.|.   ...|:..:.:|:|||:.
  Fly   300 EVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLF 364

Mouse   361 LNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENK 425
            :.|..|:||....:.|..:||..::|..:|||:|:.:....|.::.:.:.:|.:|:||||..|..
  Fly   365 IKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP 429

Mouse   426 GSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLL 484
            |   |:.|:||..|||||:|.:|||:.:|..::||::||...|..:..:    |:.|.:
  Fly   430 G---PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV----SKDGYI 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	112/480 (23%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	109/461 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810