DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp4ad1

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	124/503 - (24%)
Similarity:	231/503 - (45%)	Gaps:	83/503 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 LLAISLVL---LYRYGTR-----KHELFKKQGIPGPKPLPFLGTVLNYYKGLW-----KFDMECY 65
            |:||:::|   |...|.|     .|.....:.||||.|.||:|.:..:  ||.     |..::..
  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQF--GLKPAEYPKKVLQYC 65

Mouse    66 KKYGKTWGLFDGQTPL------LAVTDPETIKNV------LVKECFSVFTNRRDFGPVGIMSKAI 118
            :||.     |.|...|      :.::||..|:|:      |.||  .:::..|.:...|:::
  Fly    66 RKYD-----FQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKE--HLYSFLRPWLGDGLLT--- 120

Mouse   119 SISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDV 183
              |....|.:::.|.:|.|....::....|:.:.|...|:.|...:...:....::::...::|:
  Fly   121 --SSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDI 183

Mouse   184 ITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVV-----LFPFLTPVYEMLNICMFPK 243
            :...:.|.:..|||..........|.|.  |......||:|     ||. ||..|      |..:
  Fly   184 VCENATGQDSSSLNGETSDLHGAIKDLC--DVVQERTFSIVKRFDALFR-LTSYY------MKQR 239

Mouse   244 DSIEFFKKFVDRMKESRLDSKQKHRV--------------DFLQLMMNSHNNSKDKVSHKALSDM 294
            .::...     |.:.:|:.|:::|::              .||.:::.:      |:..|.|.:.
  Fly   240 RALSLL-----RSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTA------KLDGKVLKER 293

Mouse   295 EITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVM--EMEYL 357
            ||..:...|||.|::..::.:||||::|:.|.:||:|..:|.............|...  :|.||
  Fly   294 EIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYL 358

Mouse   358 DMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSK 422
            ::::.|||||||....:.|..:..:::||..:.|.:||::...|:.::.:::.:|..|:||||..
  Fly   359 ELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFEN 423

Mouse   423 E--NKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQP 468
            .  |.| |:.:..:||..|||.|:..:||:..||..|:::::.|...|
  Fly   424 PTGNVG-IEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILP 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	115/470 (24%)
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	114/468 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810