DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp3a11 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	141/522 - (27%)
Similarity:	257/522 - (49%)	Gaps:	60/522 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 VSALSLETWVLLAISLVLLYRYGTR-----KHELFKKQGIPGPKPLPFL-----GTVLNYYKGLW 58
            :|.|:|..:||.|..|    ||..:     :.:.|.|. :|||.....:     |.:||:.|
  Fly     1 MSTLALVAFVLWAAFL----RYLPKILNFLRLQRFAKT-LPGPTIGELIANVKKGEILNWLK--- 57

Mouse    59 KFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPV-GIMSKAISISK 122
                |..:|:|..:.::.|:..::..||||.||.:|...  .:.|..|::..: ..:.|.:..:.
  Fly    58 ----ELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGLLTNG 116

Mouse   123 DDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITST 187
            .:.|.|.|.||:|.|....|.|....:|:...|||:.||.|| .|:...:...:..:::|.|..|
  Fly   117 GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICET 180

Mouse   188 SFGVNVDSLNNPEDPFVEKAKKLLR------FDFFDPLLFSVVLFPFLTPVYE---MLNICMFPK 243
            :.|:...:....:..:|:..:.:.|      |.|:..|   .|.|....|..|   .|.:.....
  Fly   181 AMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRL---NVFFKHTKPGKEREAALKVLHDET 242

Mouse   244 DSIEFFKK--FVDRMKESRLDSKQ-----KHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSI 301
            :.:...::  .:....|.:.:::|     |.|:.||.:::.:......:     |||.:|..:..
  Fly   243 NRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE-----LSDTDIREEVD 302

Mouse   302 IFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLR 366
            .|:|.|::||||.::|.|..|:.:||:|::..:|..| |..:...:      |.||:.|:.||||
  Fly   303 TFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKES------MPYLEAVIKETLR 360

Mouse   367 LYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPY 431
            :||......|...:|:|:..:.:|||:::....|.||.||:::.:||.|.|:|| ..|:..:.|:
  Fly   361 IYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPF 424

Mouse   432 VYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVP 496
            .:..|..|||||:|.:||::.:|.:|..:::::.|.|.|:.| |..|: :.:.:....|.|:::|
  Fly   425 AFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PKPLA-ELVTKSGNGIRLRILP 487

Mouse   497 RD 498
            ||
  Fly   488 RD 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	127/476 (27%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	124/460 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810