DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	158/507 - (31%)
Similarity:	269/507 - (53%)	Gaps:	37/507 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 TWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLN----YYKGLWKFDMECYKKYGKT 71
            |.:||...|..|..|...:...::.:|||..:|....|....    :|..|.:...:.::...|.
  Fly     4 TLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKV 68

Mouse    72 WGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGIMSKAISISKDDEWKRYRALLSPT 136
            .|.:....|:..|.|.:.:|.||::: |:.|.:||.|....:.:...:: :.:||:..|..||||
  Fly    69 AGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDPLTANLFNL-QGEEWRNLRTKLSPT 131

Mouse   137 FTSGKLKEMF----PVIEQYG---DILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNVD 194
            |||||:|.||    .|.:|.|   |.||      ..:|..:.:.|::..|:.|||.|.:||....
  Fly   132 FTSGKMKYMFGTVSTVAQQLGGTFDELV------GSQGAVLELHDLMARYTTDVIGSCAFGTECS 190

Mouse   195 SLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEM-LNICMFPKDSIEFFKKFVDRMKE 258
            ||..|:..|.:..:::.| :....:.:.:....:|:.:.:: |.:.:...|..:||.:.|....|
  Fly   191 SLREPQAEFRQVGRRIFR-NSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVE 254

Mouse   259 SRLDSKQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLA 323
            .| :.:...|.||:.|:::.....    :.|.|:..::.||:.:|..||:||:||.:|:.|..||
  Fly   255 LR-ERENIRRNDFMDLLLDLRRQE----NGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELA 314

Mouse   324 THPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVEL---- 384
            .:.|:|:||:.||::::......||:.:|||.|||..:.||||.||..:.|.|:..:|.|:
  Fly   315 KNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPD 379

Mouse   385 --NGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMR 447
              :.|.:.||::|.||..|:|:||:.:.||.||:||||:.:......|..:|.||:|||||:|:|
  Fly   380 GGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLR 444

Mouse   448 FALMNMKLALTKIMQNFSFQ--PCKETQIPLKLSRQGL-LQPEKPIVLKVVP 496
            |..|.:|:.|..:::.|.|.  |...||  ||::::.| |.|...:.|:|.|
  Fly   445 FGRMQVKVGLITLLRRFRFSLPPGSPTQ--LKVTKRNLILLPSDGVRLQVDP 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	148/475 (31%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	148/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820