DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COMP and Comp

DIOPT Version :9

Sequence 1:	NP_000086.2	Gene:	COMP / 1311	HGNCID:	2227	Length:	757	Species:	Homo sapiens
Sequence 2:	NP_036966.2	Gene:	Comp / 25304	RGDID:	2378	Length:	755	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	689/753 - (91%)
Similarity:	713/753 - (94%)	Gaps:	1/753 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     5 TACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMEC 69
            |||||:|.||||.|:||||.|||.||.|||||||||||||||||||||||||:||||||||||||
  Rat     4 TACVLVLALAALRATGQGQIPLGGDLAPQMLRELQETNAALQDVRELLRQQVKEITFLKNTVMEC 68

Human    70 DACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTGNGSHCTDVNECNAH 134
            ||||||.:...|| ||||:..||||.|||||.|.:|.:||||||||.|:||||||||||||||||
  Rat    69 DACGMQPARTPGL-SVRPVPLCAPGSCFPGVVCTETATGARCGPCPPGYTGNGSHCTDVNECNAH 132

Human   135 PCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCIN 199
            |||||||||||||||.|||||||:|||||:||||.|||.||||||||||||||||||||||||:|
  Rat   133 PCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTFAKTNKQVCTDINECETGQHNCVPNSVCVN 197

Human   200 TRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSRSCVCAVGWAGNGI 264
            ||||||||||||||||||.||||||.|.||||||||.|||.|||:|||||||||||||||||||:
  Rat   198 TRGSFQCGPCQPGFVGDQRSGCQRRGQHFCPDGSPSPCHEKADCILERDGSRSCVCAVGWAGNGL 262

Human   265 LCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEKDNCP 329
            ||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||:||||
  Rat   263 LCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEQDNCP 327

Human   330 LVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSD 394
            |||||||||:|:||||||||||||||||||||||:||:|||||||||||||||.|||||||||.|
  Rat   328 LVRNPDQRNSDKDKWGDACDNCRSQKNDDQKDTDRDGQGDACDDDIDGDRIRNVADNCPRVPNFD 392

Human   395 QKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDS 459
            |.||||||:||||||||||.||||.|||||||||||||||||||||||||||||||||||||:||
  Rat   393 QSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQQDS 457

Human   460 DHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENA 524
            ||||:||||||||||||||||||||||||||||||.|||||||.||.|||||||:||||||||||
  Rat   458 DHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDADKVIDKIDVCPENA 522

Human   525 EVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVN 589
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||
  Rat   523 EVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVN 587

Human   590 TVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNAL 654
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   588 TATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNAL 652

Human   655 WHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRG 719
            ||||||.||||||||||||||||||.|||||||||||||||||||||||||||||||||||.|||
  Rat   653 WHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRG 717

Human   720 GRLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA 757
            |||||||||||||||||||||||||||||||.|:||:|
  Rat   718 GRLGVFCFSQENIIWANLRYRCNDTIPEDYERHRLRRA 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COMP	NP_000086.2	COMP N-terminal	22..86		53/63 (84%)
		coiled coil	30..72	CDD:293924	39/41 (95%)
		TSP-5cc	30..72	CDD:293924	39/41 (95%)
		EGF_CA	127..162	CDD:238011	32/34 (94%)
		EGF_CA	180..216	CDD:238011	34/35 (97%)
		TSP type-3 1	268..300		30/31 (97%)
		TSP3 repeat_short	268..300	CDD:275365	30/31 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..503		190/204 (93%)
		TSP_3	301..336	CDD:308167	33/34 (97%)
		TSP3 repeat_long	301..336	CDD:275366	33/34 (97%)
		TSP3 repeat_short	337..359	CDD:275366	19/21 (90%)
		TSP3 repeat_long	360..395	CDD:275365	30/34 (88%)
		Cell attachment site. /evidence=ECO:0000255	367..369		0/1 (0%)
		TSP3 repeat_short	396..418	CDD:275365	18/21 (86%)
		TSP3 repeat_long	419..456	CDD:275365	35/36 (97%)
		polyaspartate repeat	469..473		3/3 (100%)
		TSP type-3 8	493..528		30/34 (88%)
		TSP_3	493..527	CDD:308167	29/33 (88%)
		TSP3 repeat_long	493..524	CDD:275365	26/30 (87%)
		Mediates cell survival and induction of the IAP family of survival proteins	527..757		222/229 (97%)
		TSP_C	546..743	CDD:310385	191/196 (97%)
Comp	NP_036966.2	COMP N-terminal	21..84		53/63 (84%)
		TSP-5cc	29..71	CDD:293924	39/41 (95%)
		coiled coil	32..71	CDD:293924	37/38 (97%)
		EGF_CA	125..160	CDD:238011	32/34 (94%)
		EGF_CA	178..216	CDD:214542	36/37 (97%)
		TSP type-3 1	266..298		30/31 (97%)
		TSP3 repeat_short	266..298	CDD:275365	30/31 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..501		191/205 (93%)
		TSP_3	299..334	CDD:367074	33/34 (97%)
		TSP3 repeat_long	299..334	CDD:275366	33/34 (97%)
		MSCRAMM_ClfB	<311..513	CDD:411414	185/201 (92%)
		TSP3 repeat_short	335..357	CDD:275366	19/21 (90%)
		TSP3 repeat_long	358..393	CDD:275365	30/34 (88%)
		TSP3 repeat_short	395..416	CDD:275365	18/20 (90%)
		TSP3 repeat_long	417..454	CDD:275365	35/36 (97%)
		TSP type-3 8	491..526		30/34 (88%)
		TSP_3	491..525	CDD:367074	29/33 (88%)
		TSP3 repeat_long	491..522	CDD:275365	26/30 (87%)
		Mediates cell survival and induction of the IAP family of survival proteins. /evidence=ECO:0000250	525..755		222/229 (97%)
		TSP_C	544..741	CDD:399035	191/196 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83680776
Domainoid	1	1.000	412	1.000	Domainoid score	I10361
eggNOG	1	0.900	-	-		E1_2CMRF
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74
Inparanoid	1	1.050	1496	1.000	Inparanoid score	I2750
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49685
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	1	1.000	-	-		FOG0001167
OrthoInspector	1	1.000	-	-		oto129809
orthoMCL	1	0.900	-	-		OOG6_101187
Panther	1	1.100	-	-	LDO	PTHR10199
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	16.310