DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment COMP and comp

DIOPT Version :10

Sequence 1:NP_000086.2 Gene:COMP / 1311 HGNCID:2227 Length:757 Species:Homo sapiens
Sequence 2:XP_012821130.2 Gene:comp / 100494714 XenbaseID:XB-GENE-994160 Length:757 Species:Xenopus tropicalis


Alignment Length:771 Identity:532/771 - (69%)
Similarity:629/771 - (81%) Gaps:39/771 - (5%)


- Green bases have known domain annotations that are detailed below.


Human    10 LLTLAALGA-----------SGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLK 63
            :|::|.|.:           ||:|      |:|||:|.|::|||:.|::|||||::|:.||||||
 Frog     1 MLSVALLSSFCIFFGSCQQLSGRG------DVGPQLLTEMKETNSVLREVRELLKRQIEEITFLK 59

Human    64 NTVMECDACGMQQSVRTGLPSVRPLL-------HCAPGFCFPGVACIQTESGARCGPCPAGFTGN 121
            ||||||||||:..|  ||.....|.:       .|.|..||.||.||:|.||.:||.||.|:.||
 Frog    60 NTVMECDACGLHGS--TGQHFSGPGITVTSFGNKCNPNPCFSGVTCIETSSGFQCGSCPVGYLGN 122

Human   122 GSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECET 186
            |:||||:|||..:||||||||:||||||.||.||.||.|...:|:||.:|:||||:|.|:||||:
 Frog   123 GTHCTDINECTVNPCFPRVRCVNTSPGFHCEPCPIGYIGKRVEGIGLDYARANKQMCDDLNECES 187

Human   187 GQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSR 251
            |.:.|..||:|.||:||::|.||:.|    |...|  ::::.||:|..|:|||:|||:.|||||.
 Frog   188 GTNPCPANSLCTNTKGSYKCTPCKAG----QGGAC--KSEKRCPNGEISKCHENADCIKERDGSI 246

Human   252 SCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDA 316
            .|||||||||||:||.:|||:||||||||||.:.:|:||||||||||||||.||||||||||.||
 Frog   247 VCVCAVGWAGNGLLCAKDTDIDGFPDEKLRCSDVKCKKDNCVTVPNSGQEDADRDGIGDACDDDA 311

Human   317 DGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIR 381
            ||||:||.:|||..|.|.||:|.|:|.:||||||||:.|| ||.|||:||:||.||||:|||:|:
 Frog   312 DGDGIPNMQDNCIYVPNVDQKNVDQDDYGDACDNCRNVKN-DQTDTDRDGKGDVCDDDMDGDKIK 375

Human   382 NQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRD 446
            |..|||.::||.||||:||||:||.||:||...||||:|.|||.|||.||::||:|||||||:.|
 Frog   376 NAVDNCKKIPNYDQKDTDGDGVGDVCDSCPTIRNPDQSDADHDLVGDLCDTNQDRDGDGHQDTSD 440

Human   447 NCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSR----DNCRLVPNPGQEDADRDGVGDVCQDD 507
            |||:|.||.|.|:|.||.||.||:||||||:||:.    ||||:||||.|.|:|.:|:|:.|:.|
 Frog   441 NCPSVVNSDQLDTDKDGDGDECDEDDDNDGIPDTAPPGPDNCRIVPNPDQADSDGNGIGNACEGD 505

Human   508 FDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAV 572
            ||.|.||||:||||||||:|||||||:|||||||||||||||||:|||:|.||||||||||||||
 Frog   506 FDKDLVVDKVDVCPENAEITLTDFRAYQTVVLDPEGDAQIDPNWIVLNEGMEIVQTMNSDPGLAV 570

Human   573 GYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQL 637
            ||||||||||||||||||.|||||||||||||||||||.||||||||||||||||||||||||||
 Frog   571 GYTAFNGVDFEGTFHVNTETDDDYAGFIFGYQDSSSFYAVMWKQMEQTYWQANPFRAVAEPGIQL 635

Human   638 KAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEG 702
            |||||:|||||.|||:|||||||.:||:||||||||||||||.||||||||||.||||||:|:||
 Frog   636 KAVKSTTGPGEHLRNSLWHTGDTVNQVKLLWKDPRNVGWKDKTSYRWFLQHRPSVGYIRVKFFEG 700

Human   703 PELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYET--HQLRQ 756
            |||||||.||||||||||||||||||||||||:|||||||||||.|||.  .||::
 Frog   701 PELVADSGVVLDTTMRGGRLGVFCFSQENIIWSNLRYRCNDTIPNDYEAFKEQLKK 756

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
COMPNP_000086.2 COMP N-terminal 22..86 36/63 (57%)
coiled coil 30..72 CDD:293924 28/41 (68%)
TSP-5cc 30..72 CDD:293924 28/41 (68%)
EGF_CA 127..162 CDD:238011 25/34 (74%)
EGF_CA 180..206 CDD:429571 14/25 (56%)
TSP type-3 1 268..300 24/31 (77%)
TSP3 repeat_short 268..300 CDD:275365 24/31 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..503 139/208 (67%)
TSP_3 301..336 CDD:367074 25/34 (74%)
TSP3 repeat_long 301..336 CDD:275366 25/34 (74%)
TSP3 repeat_short 337..359 CDD:275366 13/21 (62%)
TSP3 repeat_long 360..395 CDD:275365 21/34 (62%)
Cell attachment site. /evidence=ECO:0000255 367..369 0/1 (0%)
TSP_3 396..456 CDD:367074 41/59 (69%)
TSP3 repeat_short 396..418 CDD:275365 14/21 (67%)
TSP3 repeat_long 419..456 CDD:275365 25/36 (69%)
polyaspartate repeat 469..473 2/3 (67%)
TSP type-3 8 493..528 21/34 (62%)
TSP_3 493..527 CDD:367074 21/33 (64%)
TSP3 repeat_long 493..524 CDD:275365 18/30 (60%)
Mediates cell survival and induction of the IAP family of survival proteins 527..757 207/232 (89%)
TSP_C 546..743 CDD:461725 179/196 (91%)
compXP_012821130.2 coiled coil 26..68 CDD:293924 28/41 (68%)
TSP-5cc 26..68 CDD:293924 28/41 (68%)
EGF 92..122 CDD:394967 16/29 (55%)
EGF_CA 128..163 CDD:238011 25/34 (74%)
EGF_CA 181..213 CDD:429571 17/31 (55%)
EGF_3 232..261 CDD:463759 22/28 (79%)
TSP3 repeat_1C 263..295 CDD:275367 24/31 (77%)
TSP3 repeat_long 296..331 CDD:275366 25/34 (74%)
TSP3 repeat_long 332..389 CDD:275366 36/57 (63%)
TSP3 repeat_short 390..412 CDD:275365 14/21 (67%)
TSP3 repeat_long 413..450 CDD:275365 25/36 (69%)
TSP_3 414..450 CDD:367074 25/35 (71%)
TSP3 repeat_short 451..490 CDD:275366 24/38 (63%)
TSP_3 491..525 CDD:367074 21/33 (64%)
TSP3 repeat_long 491..522 CDD:275365 18/30 (60%)
TSP_C 544..741 CDD:461725 179/196 (91%)

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