DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COMP and comp

DIOPT Version :9

Sequence 1:	NP_000086.2	Gene:	COMP / 1311	HGNCID:	2227	Length:	757	Species:	Homo sapiens
Sequence 2:	XP_012821130.2	Gene:	comp / 100494714	XenbaseID:	XB-GENE-994160	Length:	757	Species:	Xenopus tropicalis

Alignment Length:	771	Identity:	532/771 - (69%)
Similarity:	629/771 - (81%)	Gaps:	39/771 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    10 LLTLAALGA-----------SGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLK 63
            :|::|.|.:           ||:|      |:|||:|.|::|||:.|::|||||::|:.||||||
Frog     1 MLSVALLSSFCIFFGSCQQLSGRG------DVGPQLLTEMKETNSVLREVRELLKRQIEEITFLK 59

Human    64 NTVMECDACGMQQSVRTGLPSVRPLL-------HCAPGFCFPGVACIQTESGARCGPCPAGFTGN 121
            ||||||||||:..|  ||.....|.:       .|.|..||.||.||:|.||.:||.||.|:.||
Frog    60 NTVMECDACGLHGS--TGQHFSGPGITVTSFGNKCNPNPCFSGVTCIETSSGFQCGSCPVGYLGN 122

Human   122 GSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECET 186
            |:||||:|||..:||||||||:||||||.||.||.||.|...:|:||.:|:||||:|.|:||||:
Frog   123 GTHCTDINECTVNPCFPRVRCVNTSPGFHCEPCPIGYIGKRVEGIGLDYARANKQMCDDLNECES 187

Human   187 GQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSR 251
            |.:.|..||:|.||:||::|.||:.|    |...|  ::::.||:|..|:|||:|||:.|||||.
Frog   188 GTNPCPANSLCTNTKGSYKCTPCKAG----QGGAC--KSEKRCPNGEISKCHENADCIKERDGSI 246

Human   252 SCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDA 316
            .|||||||||||:||.:|||:||||||||||.:.:|:||||||||||||||.||||||||||.||
Frog   247 VCVCAVGWAGNGLLCAKDTDIDGFPDEKLRCSDVKCKKDNCVTVPNSGQEDADRDGIGDACDDDA 311

Human   317 DGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIR 381
            ||||:||.:|||..|.|.||:|.|:|.:||||||||:.|| ||.|||:||:||.||||:|||:|:
Frog   312 DGDGIPNMQDNCIYVPNVDQKNVDQDDYGDACDNCRNVKN-DQTDTDRDGKGDVCDDDMDGDKIK 375

Human   382 NQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRD 446
            |..|||.::||.||||:||||:||.||:||...||||:|.|||.|||.||::||:|||||||:.|
Frog   376 NAVDNCKKIPNYDQKDTDGDGVGDVCDSCPTIRNPDQSDADHDLVGDLCDTNQDRDGDGHQDTSD 440

Human   447 NCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSR----DNCRLVPNPGQEDADRDGVGDVCQDD 507
            |||:|.||.|.|:|.||.||.||:||||||:||:.    ||||:||||.|.|:|.:|:|:.|:.|
Frog   441 NCPSVVNSDQLDTDKDGDGDECDEDDDNDGIPDTAPPGPDNCRIVPNPDQADSDGNGIGNACEGD 505

Human   508 FDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAV 572
            ||.|.||||:||||||||:|||||||:|||||||||||||||||:|||:|.||||||||||||||
Frog   506 FDKDLVVDKVDVCPENAEITLTDFRAYQTVVLDPEGDAQIDPNWIVLNEGMEIVQTMNSDPGLAV 570

Human   573 GYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQL 637
            ||||||||||||||||||.|||||||||||||||||||.||||||||||||||||||||||||||
Frog   571 GYTAFNGVDFEGTFHVNTETDDDYAGFIFGYQDSSSFYAVMWKQMEQTYWQANPFRAVAEPGIQL 635

Human   638 KAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEG 702
            |||||:|||||.|||:|||||||.:||:||||||||||||||.||||||||||.||||||:|:||
Frog   636 KAVKSTTGPGEHLRNSLWHTGDTVNQVKLLWKDPRNVGWKDKTSYRWFLQHRPSVGYIRVKFFEG 700

Human   703 PELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYET--HQLRQ 756
            |||||||.||||||||||||||||||||||||:|||||||||||.|||.  .||::
Frog   701 PELVADSGVVLDTTMRGGRLGVFCFSQENIIWSNLRYRCNDTIPNDYEAFKEQLKK 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COMP	NP_000086.2	COMP N-terminal	22..86		36/63 (57%)
		coiled coil	30..72	CDD:293924	28/41 (68%)
		TSP-5cc	30..72	CDD:293924	28/41 (68%)
		EGF_CA	127..162	CDD:238011	25/34 (74%)
		EGF_CA	180..216	CDD:238011	18/35 (51%)
		TSP type-3 1	268..300		24/31 (77%)
		TSP3 repeat_short	268..300	CDD:275365	24/31 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..503		139/208 (67%)
		TSP_3	301..336	CDD:308167	25/34 (74%)
		TSP3 repeat_long	301..336	CDD:275366	25/34 (74%)
		TSP3 repeat_short	337..359	CDD:275366	13/21 (62%)
		TSP3 repeat_long	360..395	CDD:275365	21/34 (62%)
		Cell attachment site. /evidence=ECO:0000255	367..369		0/1 (0%)
		TSP3 repeat_short	396..418	CDD:275365	14/21 (67%)
		TSP3 repeat_long	419..456	CDD:275365	25/36 (69%)
		polyaspartate repeat	469..473		2/3 (67%)
		TSP type-3 8	493..528		21/34 (62%)
		TSP_3	493..527	CDD:308167	21/33 (64%)
		TSP3 repeat_long	493..524	CDD:275365	18/30 (60%)
		Mediates cell survival and induction of the IAP family of survival proteins	527..757		207/232 (89%)
		TSP_C	546..743	CDD:310385	179/196 (91%)
comp	XP_012821130.2	TSP-5cc	26..68	CDD:293924	28/41 (68%)
		EGF	92..122	CDD:394967	16/29 (55%)
		EGF_CA	128..163	CDD:238011	25/34 (74%)
		EGF_CA	181..>213	CDD:311536	17/31 (55%)
		TSP3 repeat_1C	263..295	CDD:275367	24/31 (77%)
		TSP3 repeat_long	296..331	CDD:275366	25/34 (74%)
		TSP3 repeat_long	332..389	CDD:275366	36/57 (63%)
		TSP3 repeat_short	390..412	CDD:275365	14/21 (67%)
		TSP3 repeat_long	413..450	CDD:275365	25/36 (69%)
		TSP_3	414..450	CDD:367074	25/35 (71%)
		TSP3 repeat_short	451..490	CDD:275366	24/38 (63%)
		TSP_3	491..525	CDD:367074	21/33 (64%)
		TSP3 repeat_long	491..522	CDD:275365	18/30 (60%)
		TSP_C	544..741	CDD:399035	179/196 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	395	1.000	Domainoid score	I6135
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74
Inparanoid	1	1.050	1164	1.000	Inparanoid score	I2360
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	1	1.000	-	-		FOG0001167
OrthoInspector	1	1.000	-	-		oto148642
Panther	1	1.100	-	-	LDO	PTHR10199
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160