Protein Alignment KCNH8 and CG6026

DIOPT Version :10

• Sequence 1: XP_016861187.1
• Gene: KCNH8 / 131096
• HGNCID: 18864
• Length: 1108
• Species: Homo sapiens
• Sequence 2: NP_650778.2
• Gene: CG6026 / 42287
• FlyBaseID: FBgn0038676
• Length: 1555
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 114/521 - (21%)
• Similarity: 177/521 - (33%)
• Gaps: 139/521 - (26%)

Human   648 FEVLDLYPEYAHKFVEDIQHDLTYN----------LREGHESDVISRLSNKSMVSQSEPK----- 697
            ::.:|  .|.|..|.|:   ||..|          .|:|.|...:..:....|: ||:.|
  Fly  1064 YKTID--AEAAADFEEE---DLVINDPPQPVTPGKDRKGTEETKLEPVVTLQML-QSQKKAVSLP 1122

Human   698 ----GNGNINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLAS 758
                |.|.|     .:..|.:.    :|.||..||          .:|:..:..|:...:|....
  Fly  1123 GDDTGAGEI-----QVTADNDP----QEAEASKLS----------QQKLDPSGMYVVFPMKSAEK 1168

Human   759 GTVPFHSPIRVSR-SNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPSRIVDGIEDGN 822
            |.....:|...:. .|:|.:.....|.....:.:|...||........|.|..|..|..  .|.:
  Fly  1169 GQSEGDAPSAPAEYQNTPFSVIRDQPQEPILKNKKPQSLQQQNKAQHVPKDKFPYPIEK--PDPS 1231

Human   823 SSE---ESQTFDFGSERIRSEPR-ISPPLG-DPEIGAAVLFIKAE------ETKQQINKLN---- 872
            .||   ||||...|   :...|| |:..:| ..|...|:.:...|      |..|:.:.:|
  Fly  1232 FSELHPESQTSVSG---VLVAPRIITGAMGTGTETPIAIAYTPTEPNPFRHEQGQKFSNINLATS 1293

Human   873 --SEVTTLTQEVSQLGKDMRNVIQLLE-NVLSPQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQP 934
              :|:...||....|..|.....|..| :.::|..||  .||...|
  Fly  1294 VINEIRQDTQTEEGLSSDFDLRGQNFEKDFMAPFYPS--VSLGGAS------------------- 1337

Human   935 CLHLQTGGAAYTQAQLCSSNI---TSD--IW---SVDPSSVGSSPQRTGAHEQNPADSELYHSPS 991
                  |.||...|...:.||   |:|  |:   :::.:.|.::.|:....||..|.:.....||
  Fly  1338 ------GAAAINPAAPSNWNILPSTTDQAIYEKNNINRADVETTEQKKPEEEQPTASALTAEKPS 1396

Human   992 -LD-------------YSPSHYQVVQEGHLQFLRCISPHSDSTLT-PLQSISA---TLSSSVCSS 1038
             :|             |.|.:..|.|....:.....:...|..:. ||...:|   |.:|.|.||
  Fly  1397 EMDSFQPQLQGGFKPIYPPGYKHVEQVEQEEIAGAKNAGKDQPIALPLMGTTAKPSTSASPVSSS 1461

Human  1039 SETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQE------GMASASTKPLENLPLEVVTST 1097
            |.:|            :.:..|.|:.|..:.||....:      ...:.||||.:.......||.
  Fly  1462 SSSS------------TSTSSTTSTTSTTHPPGVTKSDVTLATTKAPAISTKPTQRKKSTFETSL 1514

Human  1098 A 1098
            |
  Fly  1515 A 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH8	XP_016861187.1	PAS_9	40..135	CDD:463873
		PLN03192	175..>615	CDD:215625
		PRK11753	578..>656	CDD:236969	1/7 (14%)
CG6026	NP_650778.2	PHA03378	<792..975	CDD:223065