Protein Alignment KCNH8 and Elk

DIOPT Version :10

• Sequence 1: XP_016861187.1
• Gene: KCNH8 / 131096
• HGNCID: 18864
• Length: 1108
• Species: Homo sapiens
• Sequence 2: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Alignment Length: 1255
• Identity: 514/1255 - (40%)
• Similarity: 679/1255 - (54%)
• Gaps: 282/1255 - (22%)

Human     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSC 65
            ||..|||||||||||||||||||||||||:|.||| |.|.|||||||||.:|.|::|.::|||.|
  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64

Human    66 SCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASF 130
            ||.||:|.:|.|:...||||||..|.|.|.|::||||.|:|||||.|||||||||.||||||||.
  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129

Human   131 KDITDTKVKITPEDKKEDKV--------KGRSRAGTH---------------------------- 159
            ||||.||:.....:::.|.|        ..|.|||::
  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194

Human   160 -------FDSARRRSRAVLYHISGHLQRRE---KNKLKINNNVFVDKPA-FPEYKVSDAKKSKFI 213
                   .:..|||||||||.:|||.:..:   |.|||:.||......| |||||....|||:.|
  Fly   195 NLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLI 259

Human   214 LLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRT 278
            |.|:..||..|||:||:||||||:.||||..|...|     |.|.|||:.||.|||:||:|||||
  Fly   260 LPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD-----RQTKVSDVIVEALFIVDILLNFRT 319

Human   279 TYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNV--TVVSLVHLLKTVRLLRLLRL 341
            |:||:.|:|:..::.|.|:|:..||.:||:||||||.|||.::  ...|.:||:|..|||||.||
  Fly   320 TFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARL 384

Human   342 LQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKW----EVGWLHELGKRL 402
            |||:||||||:.::|||||..|.|.|||:|||||||...|.|      |    .:|||..|.:|
  Fly   385 LQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWLQLLAER- 442

Human   403 ESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFG 467
                 .|.::...:....|..|||||.:||||||||||||||.|||:|:|..|||||||||:|||
  Fly   443 -----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFG 502

Human   468 NVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPD 532
            ||||||||||||.|||.::.:|||||:.:|::|::||||:.:||||:||:::|||..|.|::||:
  Fly   503 NVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPE 567

Human   533 ELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSME 597
            |||.|::|||::|||||.:||.||:|||:.|||||||:||||||||:.:||||..||::|:||||
  Fly   568 ELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSME 632

Human   598 VLKDSMVLAILGKGDLIGANLSI------------------KDQVIKTNADVKALTYCDLQCIIL 644
            |:||.||:||||||||:|:::::                  :|.|:::::|:||||||||:||.:
  Fly   633 VIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHM 697

Human   645 KGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSI 709
            .||.|||.|||||..:|..|||||||.|||||:|       :..|.:..|.|         ||||
  Fly   698 GGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYE-------NQDSDIGPSFP---------LPSI 746

Human   710 VEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFH----SPIRVS 770
            .||:|..||.||            |.....:..|..           .||..|.|    ||:..:
  Fly   747 SEDDENREEAEE------------GGKGEKENGGGP-----------PSGASPLHNISNSPLHAT 788

Human   771 RS-----NSPKT-------KQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPSRIVDGIEDGNS 823
            ||     .||:.       :..|.....|||..        |||.|...|.......:.:|:..|
  Fly   789 RSPLLGMGSPRNQRLHQRGRSLITLRETNKRHR--------TLNAACSLDRGSFEEPEPLEEEQS 845

Human   824 SEESQTFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKD 888
            |        |.:|                             ..:.:|:|:|:||.|:|:||..:
  Fly   846 S--------GGKR-----------------------------PSLERLDSQVSTLHQDVAQLSAE 873

Human   889 MRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQ-------TRTSWSAHQPCLHLQTGG---A 943
            :||.|..|:.:..   .|...:.||:...|...|:.       ||:..:..    |...||   |
  Fly   874 VRNAISALQEMTF---TSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVE----HGLMGGVLAA 931

Human   944 AYTQAQLCSSNITSDIWSVD-------------PSSVGSSPQRTGAHEQNPADSELYHSPS---- 991
            |...|...||:...::|..|             ||.|  .|::|.....:..|......|:
  Fly   932 AELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPV--EPKKTMTSRSSQTDFYRIDFPTFERF 994

Human   992 -----------LDYSPS---------HYQVVQEGHLQFL-RCISPHSDSTLTPLQSISATLSSSV 1035
                       |...|:         ..|.:|...|..: .|:|| ||      .:::::....:
  Fly   995 VLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSP-SD------HNLASSKERLI 1052

Human  1036 CSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMAS---------ASTKPLENLPL 1091
            .||:..:...:.|...:|.|      :.|       .|..:..||         |...|.|..|:
  Fly  1053 TSSAVPTPGRIYPPLDDENS------NDF-------RWTMKHSASHHSCCKSTDALLSPEEQPPI 1104

Human  1092 EVV-------TSTAEVKDNK 1104
            .::       .|..||:.:|
  Fly  1105 SILPVDATPAPSVQEVRSSK 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH8	XP_016861187.1	PAS_9	40..135	CDD:463873	63/94 (67%)
		PLN03192	175..>615	CDD:215625	258/449 (57%)
		PRK11753	578..>656	CDD:236969	46/95 (48%)
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	62/92 (67%)
		PLN03192	270..>650	CDD:215625	235/396 (59%)
		cNMP	586..716	CDD:197516	71/129 (55%)