Protein Alignment KCNH8 and CngA

DIOPT Version :10

• Sequence 1: XP_016861187.1
• Gene: KCNH8 / 131096
• HGNCID: 18864
• Length: 1108
• Species: Homo sapiens
• Sequence 2: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 150/584 - (25%)
• Similarity: 267/584 - (45%)
• Gaps: 109/584 - (18%)

Human   128 ASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNK------L 186
            ||.....:...|:..|..|..|           .||.||:   |..:...|.:|.:.|      .
  Fly   186 ASDSSYVENGRKLIQEPSKRSK-----------PSALRRT---LQALRQRLTKRNRPKPPDWFLE 236

Human   187 KINNNVFVDK-----PAFPEYKVSDAKKSKFILLH----FSTFKAGWDWLILLATFYVAVTVPYN 242
            |.:|....||     ||..:..:|...:...:|.:    ..|.::.:.||.:     |::.|.||
  Fly   237 KFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAI-----VSLAVLYN 296

Human   243 VCFI------GNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTT 301
            :.|:      ...:.|........|...:.::::|.:::....::.: |.::.:|..:..||..|
  Fly   297 IIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHT 360

Human   302 --WFIIDLIAALPFDLLYAF--NVTVVSLV----HLLKTVRLLRLLRLLQKLDRYSQHST----- 353
              |: :|:::.||.||.|.:  ..|..||.    .:::..||||:.||.:..|| ::.:|
  Fly   361 KGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDR-TETATGYPNA 423

Human   354 -----IVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVG-----WLHEL-GKRLESPYY 407
                 :||.:|     :|.||.||:::.|           .:|:|     |::.| |.|
  Fly   424 FRICKVVLAIL-----VLIHWNACMYFAI-----------SYEIGFSSDSWVYNLNGTR------ 466

Human   408 GNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAI 472
             ||||     :..||.:.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.::
  Fly   467 -NNTL-----QRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSM 524

Human   473 IQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD 537
            |..|......:..|...:|.::....:..:|:.|::.:|..|||.:..:|...:|...||:|:::
  Fly   525 ISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAE 589

Human   538 ITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKD 601
            |.:.::.:.| |:.:|.....|.|.:|.|.:|....:||:|:.|:||..:.:|.|..|.:.|:.|
  Fly   590 IAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGD 654

Human   602 S--MVLAILGKGDLIGANLSIKDQVIKTN-------ADVKALTYCDLQCIILKGLFEVLDLYPE 656
            .  .|||.||.|.:.| .:|:.:  |..|       |:|::|.|.||.|:..:.|:|.|..|||
  Fly   655 DGITVLATLGAGSVFG-EVSVLE--IAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPE 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH8	XP_016861187.1	PAS_9	40..135	CDD:463873	2/6 (33%)
		PLN03192	175..>615	CDD:215625	122/487 (25%)
		PRK11753	578..>656	CDD:236969	29/86 (34%)
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	70/283 (25%)
		CAP_ED	604..717	CDD:237999	40/115 (35%)
		CLZ	720..790	CDD:465160