DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp2j5 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_034137.1	Gene:	Cyp2j5 / 13109	MGIID:	1270149	Length:	501	Species:	Mus musculus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	132/481 - (27%)
Similarity:	232/481 - (48%)	Gaps:	54/481 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 VTFLFLINILR-----SRHPKNYPPGPWRLPFVGNFFQIDTKQTHLVL---------QQFVKKYG 76
            |.::|...:|.     .|.||.:||||...|.||:..|:...:..|.:         :|:|..||
  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69

Mouse    77 NVFSLELGQSPVVVVSGLPLIKEMFTHLD-----QNFVNRFMTPVRERITGKNGLVVSNGQTWKE 136
             .:.|::|:..||:......|.||.|:.|     .....|..|     ...:.|:::::|:.|.|
  Fly    70 -FYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPDGIFYRLRT-----FNSRLGVLLTDGEMWVE 128

Mouse   137 QRRLALMALRNFGLGKKSLEERIQEETHHLVEAIREE----GGQPFNPHLKLINA--VSNIICSV 195
            |||..|..|:|||..:..:.:.:..|...|::.::::    ||:.....:..:.:  |.|.:..:
  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCM 193

Mouse   196 TFGERFDYEDCQFQELLQLLDETMHLMGS--SAGQLYNGFPCIMKYLPG---------PHQKIFR 249
            ..|.|::...   .|:.|||:....|..:  ..|.|::.||.:....|.         .|:.::
  Fly   194 LSGRRYEPGS---PEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLY- 254

Mouse   250 NWGKLKLFVSHIVKKHEKDW-NPDEPRDFIDAFLIEMQKDPDRTTSFNEENLISTTLDLFLGGTE 313
                  .|:|..::.|...: |.|||||.:|::|....:..|....|::::|::..||:||.|:|
  Fly   255 ------TFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAICLDMFLAGSE 313

Mouse   314 TTSSTLRWALLYMSSYPEIQENVQAEIDRVIGHKRQVSLS-DRESMPYTNAVIHEVQRMGNIVPL 377
            ||:.:|.:..:::...|||||....||..|:|.:|....| ||..:||..|:..|..||..:...
  Fly   314 TTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTF 378

Mouse   378 NSSREVTVDTKFNGFHLPKGTMILTNLTALHRDPKEWATPEVFNPEHFLENGQFKKRESFLPFSM 442
            ........||:.:|:.:||.||::.....:..:|.::..||.|||:.:|.:|..|..|:|.||..
  Fly   379 GIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDGHLKLPEAFNPFGF 443

Mouse   443 GKRACLGEQLAKSELFIFFSALMQKF 468
            |:..|:|:.|.:..||:|.:.::|.|
  Fly   444 GRHRCMGDLLGRQNLFMFTTTVLQNF 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2j5	NP_034137.1	p450	44..496	CDD:278495	126/458 (28%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	126/458 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820