DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp2f2 and spo

DIOPT Version :9

Sequence 1:	NP_031843.2	Gene:	Cyp2f2 / 13107	MGIID:	88608	Length:	491	Species:	Mus musculus
Sequence 2:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	141/546 - (25%)
Similarity:	238/546 - (43%)	Gaps:	106/546 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 AILLLLLAVISLSLTFSSRGKGQLP--------------------PGPKPLPILGNLLQL-RSQD 50
            ||||.:||...:.:.:..:.:...|                    |||:|.||:|||..| |.:|
  Fly    11 AILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRD 75

Mouse    51 L-LTSLTKLSKEYGSVFTVYLGSRPVIVLSGYQTVKEALVDKGEEFSGRG---AYPVFFNFTRGN 111
            . ....|.|:::||.::::..|....:|::..:.::|.|...|:..|||.   .|...|...|.|
  Fly    76 SPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGERSN 140

Mouse   112 GIAFSDGERWKIL--------------RRFSVQILRNFGMGKRSIEERILEEGSFLLEVLRKMEG 162
            .:|..|   |..|              |.||...::...:|...:|....|.|:.|      :.|
  Fly   141 SLALCD---WSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQL------VPG 196

Mouse   163 KPFDPVFILSRSVSNIICSVVFGSRFDYDDERLLTIIHF-------INDNFKIMSSPWGEMYNIF 220
            :|.:...::.::.:|:....:...||||||.....|:.:       ||....:...||  :|..:
  Fly   197 EPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPW--LYPFY 259

Mouse   221 P----SVLDWIPGPHKRLFRNFGGMKDLIARSVREHQDSLDPNSP-RDFIDCFLTKMAQEKQDPL 280
            .    .:::|     ....|.|     ::.|.:|..:.|:|.:.| |||.|..|..:.::|.
  Fly   260 QRHLNKIINW-----SSTIRGF-----IMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKD--- 311

Mouse   281 SHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDRVV-GRSRMPTLEDRT 344
              .:.:|::....:.: ||...||..:......:.|...:..|:|||||.:: ..:|...|.|..
  Fly   312 --VSRNTIIFMLEDFI-GGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMN 373

Mouse   345 SMPYTDAVIHEVQRFADVIPMNLPHRVTRDTPFRGFLIPKGTDVITLLNTVHYDSDQF-KTPQEF 408
            :||||.|.|.||.|::. .|: :||..|.||...|:.:.||| ::.:.|.|...|::| ..|:||
  Fly   374 AMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGT-IVFINNYVLNTSEKFWVNPKEF 435

Mouse   409 NPEHFLD-------------------DNHSF---KKSPAFMPFSAGRRLCLGEPLARMELFIYFT 451
            ||..||:                   ||...   :..|.|:|||.|:|.|:|:.|.|...|:...
  Fly   436 NPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVV 500

Mouse   452 SILQNFTLQPLVDPEDIDLTPLSSGL 477
            :::|.:.:.. .:|..|.::|.|..|
  Fly   501 NVMQRYNISS-HNPSTIKISPESLAL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2f2	NP_031843.2	p450	31..488	CDD:278495	135/522 (26%)
spo	NP_001286943.1	p450	56..540	CDD:299894	134/501 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920