Protein Alignment Cyp2e1 and Cyp304a1

DIOPT Version :9

• Sequence 1: NP_067257.1
• Gene: Cyp2e1 / 13106
• MGIID: 88607
• Length: 493
• Species: Mus musculus
• Sequence 2: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 159/522 - (30%)
• Similarity: 252/522 - (48%)
• Gaps: 59/522 - (11%)

Mouse     6 ITVALL-VWIATLLLVSIWKQIYRSWNLPPGPFPIPFFGN-IFQL--DLKDIPKSLTKLAKRF-G 65
            ||..|| :..|..|.:|....:.|....||||..||.||: :|.|  :.|.:.|:...|::.: .
  Fly     2 ITETLLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKS 66

Mouse    66 PVFTLHLGQRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVF------QEYKNKGIIFNNGPTWKD 124
            .:..||:|...:.|:|....|:|:|.|  ..|.||..:.|.      |:.  :||.|.:||.||:
  Fly    67 DIIGLHVGPFPVAVVHSADGVREILNN--QVFDGRPQLFVAAMRDPGQDV--RGIFFQDGPLWKE 127

Mouse   125 VRRFSLSILRDWGMGKQGN--EARIQREAHFLVEELKKTKGQPFDPTFLIGCAPCNVIADILF-- 185
            .|||.|..|||:|.|::.:  |..||.:.:.:::.::.....|.:.. ::......|:..:||
  Fly   128 QRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHE-MVKSGGYRVLLPLLFNP 191

Mouse   186 ---NKRFDYDDKKCL------ELMSL------FNENF-----YLLSTPWIQAYNYFSDYLQYLPG 230
               |..|.....:||      :|:.|      |..|.     .|...|||:  :.:.::..|
  Fly   192 FSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIR--HIWPEWSGY--- 251

Mouse   231 SHRKVMKNVSEIRQYTLGKAKEHLKSLDINCPRDVTDCLLIEMEKEKHSQEPMYTMENISVTLAD 295
              .|:.::...:||:......::|.|.:....|:..|..:.||.:     .|.|......:.:..
  Fly   252 --NKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRR-----GPGYGFNRDQLIMGL 309

Mouse   296 LFFAGTETTSTTLRYGLLI--LMKYPEIEEKLHEEIDRVIGPSRAPAVRDRMNMPYMDAVVHEIQ 358
            :.|:....|:..::..||:  ||.||.:..::..|||.|:|..|.|.:.||.|:|:.:|.:.|..
  Fly   310 VDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGL 374

Mouse   359 RFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYEFPDPETFKPEHFLNENGKFKY 423
            |...||||::||:|..||...||.|||.|:|:|:|.:...|...:.|||.|:||.||:.:||...
  Fly   375 RIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCL 439

Mouse   424 S-DYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKD--IDLSPVTIGFGSIPREF 485
            . |....|.||||:|.||..||..|||:.:.:.|||:.  ::.|.|  .|||....|....|.:|
  Fly   440 KLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPDF 502

Mouse   486 KL 487
            .|
  Fly   503 WL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2e1	NP_067257.1	p450	44..489	CDD:278495	143/483 (30%)
		Substrate binding. /evidence=ECO:0000250	298..303		1/4 (25%)
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	150/492 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910