DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp2c40 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_034134.3	Gene:	Cyp2c40 / 13099	MGIID:	1306815	Length:	491	Species:	Mus musculus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	126/478 - (26%)
Similarity:	224/478 - (46%)	Gaps:	35/478 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 VVLVLCLSFLLVLSLWRQRSARGNLPPGPTPLPIIGNYHLIDM---------KDIGQCLTNFSKT 60
            |:.:.|.:.|.:|....::..|  .||||...||:|:...:..         |.|......:...
  Fly     5 VIWIFCATLLAILFGGVRKPKR--FPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67

Mouse    61 YGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEEFSGRGRIP--VFDKVSTGK---GIGFSHGNVW 120
            || .:.|..|...:|:.:..:||.|.:.:  |:..||   |  :|.::.|..   |:..:.|.:|
  Fly    68 YG-FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGR---PDGIFYRLRTFNSRLGVLLTDGEMW 126

Mouse   121 KATRVFTVNTLRNLGMGKRTIENKVQEEAQWLMKELK----KTNG--SPCDPQFIIGCAPCNVIC 179
            ...|.|.:..|:|.|..:..:.:.|..||..|:::||    |:.|  :..:...:......|.:.
  Fly   127 VEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLW 191

Mouse   180 SIVFQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCP--GSHNKLFKNHTWIKS 242
            .::...|::....:...|:....|..:.:...|. :|:..|:|....|  ..:|...::|..:.:
  Fly   192 CMLSGRRYEPGSPEITQLLETFFELFKNIDMVGA-LFSHFPLLRFIAPNFSGYNGFVESHRSLYT 255

Mouse   243 YLLGKIKEHEESL-DVTNPRDFIDYFLIQRRQKNGIEHMDYTIEHLATLVTDLVFGGTETLSSTM 306
            ::..:|:.|..:. :...|||.:|.:|..:.:.|..:.| ::.:.|..:..|:...|:||.:.::
  Fly   256 FMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGM-FSDQSLLAICLDMFLAGSETTNKSL 319

Mouse   307 RFALLLLMKHTHITAKVQEEIDNVIGRHRSP-CMQDRNHMPYTNAMVHEVQRYIDLGPNGVVHEV 370
            .|..:.|:....|..:..:||..|:|..|.| ..:||..:||..|:..|..|...|...|:.|..
  Fly   320 GFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRA 384

Mouse   371 TCDTKFRNYFIPKGTQVMTSLTSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRIC 435
            .|||:...|.|||.|.|:.....:|.:..:||:||.|:|..:|.| |:.|..:.|.||..|:..|
  Fly   385 VCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRC 448

Mouse   436 VGESLARMELFLFLTTILQNFKL 458
            :|:.|.|..||:|.||:|||||:
  Fly   449 MGDLLGRQNLFMFTTTVLQNFKM 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2c40	NP_034134.3	p450	30..487	CDD:333810	121/453 (27%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	121/453 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920