DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp2b13 and Cyp303a1

DIOPT Version :9

Sequence 1:	XP_006539571.1	Gene:	Cyp2b13 / 13089	MGIID:	88599	Length:	517	Species:	Mus musculus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	146/505 - (28%)
Similarity:	237/505 - (46%)	Gaps:	59/505 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 PGVGWIILMIAGL----LRKVYGAVEQTMDVRGKQNALVIQHAPLDQRLQEKHGDVFTVHLGPRP 100
            ||..|..::.:.|    ||...|...:.:||..:|..             ..:| .:.:.:|...
  Fly    29 PGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYV-------------NPYG-FYGLKIGKDK 79

Mouse   101 VVVLCGTQTIREALVNNAEAFSGR--GTIAAAQLVMQDYGIFFSSGERWKTLRRFSLATMKEFGM 163
            ||:......|.|.:.|  |...||  |.....:......|:..:.||.|...|||.|..:|.||.
  Fly    80 VVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGF 142

Mouse   164 GKRSVEERIKEEAQCLVEELK----KYQGAPL-----DPTFFFQCVTANIICSIVFGERFDYTDE 219
            .:..:.:.:..||.||:::||    |..|...     |.|..:   ..|.:..::.|.|::....
  Fly   143 ARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVY---VLNTLWCMLSGRRYEPGSP 204

Mouse   220 QFLRLLNLMYQIYSLLRSFSCQMFELFSGLLKYFPGVHRQIAKN----------QQEILNFITHR 274
            :..:||...::::        :..::...|..:|| :.|.||.|          .:.:..|::..
  Fly   205 EITQLLETFFELF--------KNIDMVGALFSHFP-LLRFIAPNFSGYNGFVESHRSLYTFMSKE 260

Mouse   275 VEKHRATL-DPSEPRDFIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGTETTSTTLCCGFL 338
            :|.||.|. :..||||.:|:| ||.:.|.::....|..|:|:...|.:|.||:|||:.:|...|:
  Fly   261 IELHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFM 324

Mouse   339 LMLMYPHVAEKVQKEIDQVIGSHRLPTLD-DRTKMPYTDAVIHEIQRFSDIVPTGAPHRVTKDTM 402
            .:::.|.:.|:..:||.:|:|..|:|... ||||:||.:|:..|..|...:...|.|||...||.
  Fly   325 HLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTR 389

Mouse   403 FRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESI 467
            ..||.:||:|.|.......|.:|..|..|:|||||.:| .:|.||..|||.||..|:..|:|:.:
  Fly   390 LSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCMGDLL 453

Mouse   468 ARNELFLFFTSILQNFSVASPVASKDIDLTPKESGIGKIPPTYQICFLAR 517
            .|..||:|.|::||||.:.: :..:..:..|.|.....:.| |.|..:||
  Fly   454 GRQNLFMFTTTVLQNFKMVA-IPGQVPEEVPLEGATAAVKP-YDIMLVAR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2b13	XP_006539571.1	p450	82..514	CDD:365848	134/454 (30%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	139/481 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820