DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp2b10 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_034129.1	Gene:	Cyp2b10 / 13088	MGIID:	88598	Length:	491	Species:	Mus musculus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	161/525 - (30%)
Similarity:	252/525 - (48%)	Gaps:	77/525 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 LLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLLQMDRGGLLKSFIQLREKYG------DVF 66
            |||:|.|       |..|.: .|||||...|::|:.||:.         |||.:.|      |||
  Fly    13 LLAILFG-------GVRKPK-RFPPGPAWYPIVGSALQVS---------QLRCRLGMFCKVIDVF 60

Mouse    67 T-----------VHLGPRPVVMLCGTDTIREALVGQAEAFSGR--GTVAVVEPTFKEYGVIFANG 118
            .           :.:|...||:....|.|.|.:..  |...||  |....:.......||:..:|
  Fly    61 ARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDG 123

Mouse   119 ERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELR----KSQG--APLDPTFLFQCITAN 177
            |.|...|||.|..:::||..:..:.:.:..||.||:::|:    ||.|  ..::...|......|
  Fly   124 EMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLN 188

Mouse   178 IICSIVFGERFEYTDRQFLRLLELFYQTFSLIS------------SFSSQMFELFSGFLKYFPGA 230
            .:..::.|.|:|....:..:|||.|::.|..|.            .|.:..|..::||::    :
  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVE----S 249

Mouse   231 HRQISKNLQELLDYIGHSVEKHRATL-DPSVPRDFIDIYLLRMEKEKSNQHTEFHHQNLMMSVLS 294
            ||       .|..::...:|.||.|. :...|||.:|.| ||.:.|.:::...|..|:|:...|.
  Fly   250 HR-------SLYTFMSKEIELHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLD 306

Mouse   295 LFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLD-DRTKMPYTDAVIHEIQR 358
            :|.||:||::.:|.:.|:.::..|.:.|:..:||.:|:|..|:|... ||||:||.:|:..|..|
  Fly   307 MFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVR 371

Mouse   359 FSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKS 423
            ...|...|:|||...||...||.:||:|.|.......|.:|..|..|:|||||.:| .:|.||..
  Fly   372 MFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLP 435

Mouse   424 EAFLPFSTGKRICLGESIARNELFLFFTSILQNFSVAS--HVAPKDIDLTPKESGIGKIPPTYQI 486
            |||.||..|:..|:|:.:.|..||:|.|::||||.:.:  ...|:::   |.|.....:.| |.|
  Fly   436 EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEV---PLEGATAAVKP-YDI 496

Mouse   487 CFLAR 491
            ..:||
  Fly   497 MLVAR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2b10	NP_034129.1	p450	42..488	CDD:278495	145/486 (30%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	145/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820