DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp2a4 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_034127.2	Gene:	Cyp2a4 / 13086	MGIID:	88596	Length:	494	Species:	Mus musculus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	134/496 - (27%)
Similarity:	234/496 - (47%)	Gaps:	53/496 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 KLPPGPTPLPFVGNFLQLNTEQ----MYNSLMKISQR-----YGPVFTIYLGSRRIVVLCGQETV 87
            :.||||...|.||:.||::..:    |:..::.:..|     || .:.:.:|..::|:....:.:
  Fly    26 RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIGKDKVVIAYTNDAI 89

Mouse    88 KEALVDQAEEFSGRGE-----QATFDWLFKGYGIAFSSGERAKQLRRFSITTLRDFGVGKRGIEE 147
            .|.:.:  |:..||.:     ..||:   ...|:..:.||...:.|||.:..|::||..:.|:.:
  Fly    90 SEMMTN--EDIDGRPDGIFYRLRTFN---SRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMD 149

Mouse   148 RIQEEAGFLI----DSFRKTNG--AFIDPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMML 206
            .:..||..|:    |...|:.|  ..|:.....|..|.|.:..::.|.|::....|...||.
  Fly   150 IVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLE--- 211

Mouse   207 GSLQFTATSMGQVYEMFSSVMKHLP-----GPQQQAF----KELQGLEDFITKKVE-HNQRTLDP 261
                 |...:.:..:|..::..|.|     .|....:    :..:.|..|::|::| |.....:.
  Fly   212 -----TFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNY 271

Mouse   262 NSPRDFIDSFLIRMLEEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKYPDIEAK 326
            :.|||.:||:| |..:|..:....|..::|:...|::|.||:||.:.:|.:.|:.|:..|:|:.:
  Fly   272 DEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQER 335

Mouse   327 VHEEIDRVIGRNRQPKY-EDRMKMPYTEAVIHEIQRFADLIPMGLARRVTKDTKFRDFLLPKGTE 390
            ..:||..|:|..|.|:: .||.|:||.||:..|..|...|...|:..|...||:...:.:||.|.
  Fly   336 AFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTM 400

Mouse   391 VFPMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFLTN 455
            |......:|.:|..|.:|:.|||..:|.| |..|..:||.||..|:..|.|:.|.|..||:|.|.
  Fly   401 VIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTT 464

Mouse   456 IMQNFHFKST--QEPQDIDVSPRLVGFVTIPPTYTMSFLSR 494
            ::|||...:.  |.|:::.    |.|.......|.:..::|
  Fly   465 VLQNFKMVAIPGQVPEEVP----LEGATAAVKPYDIMLVAR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2a4	NP_034127.2	p450	34..491	CDD:278495	133/489 (27%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	129/467 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820