DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp2a4 and spo

DIOPT Version :9

Sequence 1:	NP_034127.2	Gene:	Cyp2a4 / 13086	MGIID:	88596	Length:	494	Species:	Mus musculus
Sequence 2:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	137/533 - (25%)
Similarity:	230/533 - (43%)	Gaps:	88/533 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 LLLVAAVAFLSVL------VLMSVWKQRKLSGKL----------PPGPTPLPFVGN--FLQLNTE 52
            ||.|.|.:::.::      ||..|  :.|.|.::          .|||.|.|.:||  .|....:
  Fly    13 LLSVLATSYICIIYGVKRRVLQPV--KTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRD 75

Mouse    53 QMYNSLMKISQRYGPVFTIYLGSRRIVVLCGQETVKEALVDQAEEFSGRGEQATFDWLFKG---Y 114
            ..:.....::|:||.::::..|..|.:|:...|.::|.|....:..|||.:...:..||.|   .
  Fly    76 SPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGERSN 140

Mouse   115 GIAFSSGERAKQLRR-----------FSITTLRDFGVGKRGIEERIQEEAGFLIDSFRKTNGAFI 168
            .:|.....:.:|.||           ||...::...:|...:|...:|....|:.      |..|
  Fly   141 SLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLVP------GEPI 199

Mouse   169 DPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSLQFTATSMGQVYE----MFSSVMKH 229
            :....:.:..:|:.|..:...||||:|.:|..:::..  ...|...:.|...:    ::....:|
  Fly   200 NIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYF--DEIFWEINQGHPLDFLPWLYPFYQRH 262

Mouse   230 LPGPQQQAFKELQGLEDFITKK-VEHNQRTLDPNSP-RDFIDSFLIRMLEEKKNPNTEFYMKNLV 292
            |    .:.......:..||.:: :.|.:.::|.:.| |||.|:.|..:||:|.      ..:|.:
  Fly   263 L----NKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKD------VSRNTI 317

Mouse   293 LTTLNLFFAGTETVSTTLRYGFLLLMKYPDIEAKVHEEIDRVI-GRNRQPKYEDRMKMPYTEAVI 356
            :..|..|..|...|...:......:.|..||..::.||||.:| ..||.....|...||||.|.|
  Fly   318 IFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATI 382

Mouse   357 HEIQRFAD--LIPMGLARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLD- 418
            .|:.|::.  ::|    ...|:||....:.:.|||.||.....:....||:.|||:|||..||:
  Fly   383 FEVLRYSSSPIVP----HVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNPLRFLEP 443

Mouse   419 --------------------DKGQFKKS-DAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHF 462
                                :|.|.|:: ..|:|||||||.|.|:.|.|...||.:.|:||.::.
  Fly   444 SKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNI 508

Mouse   463 KSTQEPQDIDVSP 475
             |:..|..|.:||
  Fly   509 -SSHNPSTIKISP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp2a4	NP_034127.2	p450	34..491	CDD:278495	128/489 (26%)
spo	NP_001286943.1	p450	56..540	CDD:299894	128/488 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010