DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp26a1 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_031837.2	Gene:	Cyp26a1 / 13082	MGIID:	1096359	Length:	497	Species:	Mus musculus
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	111/499 - (22%)
Similarity:	192/499 - (38%)	Gaps:	101/499 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    27 LWDLYCVSS-----------------RDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRK 74
            ||:.:.:.:                 :||..|...|     ..:||....|.|::|....:....
  Fly     2 LWEFFALFAIAAALFYRWASANNDFFKDRGIAYEKP-----VLYFGNMAGMFLRKRAMFDIVCDL 61

Mouse    75 YGFIYKTHLFG-----RPTVRVMGADNVRRILLGE------HRLV----SVHWPASVRTILGAGC 124
            |........||     :|.:.|...|.:::|.:.:      ||.|    |...|..:..:.|:.
  Fly    62 YTKGGSKKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSS- 125

Mouse   125 LSNLHDSSHKQRKKVIMQAFS----REALQCYVPVIAEEVSSCLEQWLSCGERGLLVYPEVKRLM 185
            |.::.|:..|..:..:..||:    |:..| .:..:|:|...||:|..|..:...|   ::|...
  Fly   126 LFSMRDARWKDMRSTLSPAFTGSKMRQMFQ-LMNQVAKEAVDCLKQDDSRVQENEL---DMKDYC 186

Mouse   186 FRIAMRILLGCEPG-PAGGGEDEQQLVEAFEEMTRNL--FSLPIDVPFSGLYRGVKARNLIHARI 247
            .|....::.....| .....:|.:   ..|.:|.:.|  |:....:.|. |:..:|..|.| .::
  Fly   187 TRFTNDVIASTAFGLQVNSFKDRE---NTFYQMGKKLTTFTFLQSMKFM-LFFALKGLNKI-LKV 246

Mouse   248 EENIRAKIR---RLQATEPDGGCKDALQLLIEHSWERGERLDM---------------QALKQSS 294
            |...|...:   ||        ..||::...||:..|.:.::|               .|:::.|
  Fly   247 ELFDRKSTQYFVRL--------VLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWS 303

Mouse   295 TE--------LLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSNQD---NKLDME 348
            ..        ..|.|.||:|.........|.....|.|::.||::      :.:||   .:|..|
  Fly   304 DRDIVAQCFVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQ------QVDQDLEGKELTYE 362

Mouse   349 TLEQLKYTGCVIKETLRLNPPVPGGFRVALK--TFELNG--YQIPKGWNVIYSICDTHDVADIFT 409
            .:..:||...|:.|.||..|......|...|  ||:::|  .::.||..:....|..|.....|.
  Fly   363 AIMGMKYLDQVVNEVLRKWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFE 427

Mouse   410 NKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKILLK 453
            |..:|:|:||...:.|....|::.|||.|.|:|:|..||.:..|
  Fly   428 NPMKFDPERFSDENKESIQPFTYFPFGLGQRNCIGSRFALLEAK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp26a1	NP_031837.2	p450	43..491	CDD:299894	106/466 (23%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	106/465 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030