DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp26a1 and Cyp4p3

DIOPT Version :9

Sequence 1:	NP_031837.2	Gene:	Cyp26a1 / 13082	MGIID:	1096359	Length:	497	Species:	Mus musculus
Sequence 2:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	116/490 - (23%)
Similarity:	196/490 - (40%)	Gaps:	80/490 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    31 YCV-----------SSRDRSCALPLPPGTM----GFPFFGETLQMVLQRRKFLQMKRRKYGFIYK 80
            ||:           :.::.....||..|:.    .|..:|:....|.:..:..   .:|.|..|.
  Fly    24 YCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGKDHSGVFEHSRDC---AKKLGKSYA 85

Mouse    81 THLFGRPTVRVMGADNVRRILLGEHRLVS-------VHWPASVRTILGAGCLSNLHDSSHKQRKK 138
            .:..|.....|:.||:..|: |.:..|::       :|      ..|..|.|::.....| .|:|
  Fly    86 EYAMGTAIYNVIDADSAERV-LNDPNLINKGTIYDFLH------PFLRTGLLTSTGKKWH-ARRK 142

Mouse   139 VIMQAFSREALQCYVPVIAEEVSSCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGC---EPGP 200
            ::...|....|..:..:...|....|||:....|..:.:...:.|..........:|.   |...
  Fly   143 MLSPTFHFNILNQFQEIFITESLKFLEQFKGNDEAIISLNEVIPRFTLNSICETAMGVKLDEMAE 207

Mouse   201 AGG--GEDEQQLVEAFEEMTRN-------LFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIR 256
            .|.  .|:.:|:.|.|.....|       ||.:..:..::      .|.:::|. ....|.||.|
  Fly   208 KGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAEKDYA------SALDVVHG-FSSEIIAKRR 265

Mouse   257 RLQATEPD--GGCKDALQLLIEHSWERGERLDMQALKQSS------------TELLFGGHETTAS 307
            .....|.|  |..:.|...|.. |.:|...||...|.:..            ..|:|.|::||:.
  Fly   266 DQLNDEIDSRGNTQTAEDELFT-SKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFEGYDTTSI 329

Mouse   308 AATSLITYLGLYPHVLQKVREEIKSKGLLCKSNQD---NKLDMETLEQLKYTGCVIKETLRLNPP 369
            .....:..:.|||...:|..:||       ::|.|   |.|::..|.:||.....||||:||.|.
  Fly   330 GLMFGLMNMSLYPEEQEKCYQEI-------QANIDDELNILNIGQLNKLKNLEYFIKETMRLFPS 387

Mouse   370 VPGGFRVALKTFEL-NGYQIPKGWNVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDASRFSFI 433
            ||...|...:..|| ||..:|||..:...:.|.|...:.:.:.|||.|:||:..:.::...:::|
  Fly   388 VPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYI 452

Mouse   434 PFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468
            ||..|.|:|:|::||...:|...|.|.:  .:|:|
  Fly   453 PFSAGQRNCIGQKFAMQEMKTLMVALLK--QFQIL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp26a1	NP_031837.2	p450	43..491	CDD:299894	114/467 (24%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	111/460 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000