DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp26a1 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_031837.2	Gene:	Cyp26a1 / 13082	MGIID:	1096359	Length:	497	Species:	Mus musculus
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	121/503 - (24%)
Similarity:	217/503 - (43%)	Gaps:	75/503 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MGLPALLASALCTFVLPLLL-------FLAALKLWDLYCVSSRDRS---CALPLPPGTMGFPFFG 55
            :|:|.|||      ||.|||       |:.:|    ...|.:.|.|   ..:.:.||...   ||
  Fly     6 LGIPILLA------VLTLLLKHINKTYFILSL----TKRVRTEDGSPLESKVAIMPGKTR---FG 57

Mouse    56 ETLQMV---------LQRRKFLQMKRRKY--GFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVS 109
            ..|.::         ..|....:.|.:.|  .|:|      .|...|:..:....:......:..
  Fly    58 NNLDILNFTPASVFNFVRESTAKAKGQNYLWYFLY------APMYNVVRPEEAEEVFQSTKLITK 116

Mouse   110 VHWPASVRTILGAGCLSNLHDSSHK--QRKKVIMQAFSREALQCYVPVIAEEVSSCLEQWLSCGE 172
            ......:|..||.|.|.:   :.||  .|:|.:..||....||.::.:..||   | :::|:..|
  Fly   117 NVVYELIRPFLGDGLLIS---TDHKWHSRRKALTPAFHFNVLQSFLGIFKEE---C-KKFLNVLE 174

Mouse   173 RGLLVYPEVKRLMFRIAMRIL----LGCEPGPAGGGEDEQQLVEAFEEMTRNLFSLPIDVPFS-- 231
            :.|....|:.:::....:..:    ||.:......|.:.::.:.|.||:.......|: :.::
  Fly   175 KNLDAELELNQVIPPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPL-MYYNWY 238

Mouse   232 ----GLYR-GVKARNLIH---ARIEENIRAKIRRLQATEPDG-GCKD---ALQLLIEHSWERGER 284
                |.|| .::...::|   :||.|..|.:.::.|..|.|. |.|.   .|..|:  :.|...:
  Fly   239 FFVYGDYRKHLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLL--AAEADGQ 301

Mouse   285 LDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSNQDNKLDMET 349
            :|.|.:.......:|.|::||::.....:..|.|:..|.:|..||:::   |.:.:.|  :.|..
  Fly   302 IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVEN---LPEDSDD--ISMFQ 361

Mouse   350 LEQLKYTGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADIFTNKEEF 414
            ..:|.|..|||||:||:.|.||...|..::...:||..:||...:...|.|.......|...:.|
  Fly   362 FNKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLF 426

Mouse   415 NPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH 462
            .||||:..:..:...|:::||..|.|:|:|::||.:.:|:....:.|:
  Fly   427 QPDRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRN 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp26a1	NP_031837.2	p450	43..491	CDD:299894	106/451 (24%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	99/410 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000