Protein Alignment Cyp24a1 and Cyp12a5

DIOPT Version :9

• Sequence 1: NP_034126.1
• Gene: Cyp24a1 / 13081
• MGIID: 88593
• Length: 514
• Species: Mus musculus
• Sequence 2: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 136/539 - (25%)
• Similarity: 238/539 - (44%)
• Gaps: 71/539 - (13%)

Mouse    23 QPPRSVTSKAHVKRAPKEVPLCPLMTDGE---TRNVTSLPGPTNWPLLGSLLEIFWKGGLK---- 80
            |..:.:...|..:|....||...:..|.|   .:....:|       ..::|.:|.|..|.
  Fly    12 QSQKPIVFSASQQRWQTNVPTAEIRNDPEWLQAKPFEEIP-------KANILSLFAKSALPGGKY 69

Mouse    81 ---KQHDTLAEYHKKYGQIFRM--KLGSFDSVHLGSPSLLEALYRTESAHPQR-----LEIKPWK 135
               :..:.:....:.||.|..:  .:|....|...:|...|.::|.|...|.|     |......
  Fly    70 KNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTV 134

Mouse   136 AYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFMGQIDELRDERGRI 200
            ..:|..:...|::..:|:.|...||.....||:|..:....||:::|..:|:..|.|:||  ...
  Fly   135 YRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRD--AST 197

Mouse   201 QDL----YSELNKWSFESICLVLYEKRFGLLQKDTEEEALTFI----------AAIKTMMSTFGK 251
            |::    ...:|:|:.||:.:|..:|:.|||::..:....|.:          :|...|..:..:
  Fly   198 QEVPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWR 262

Mouse   252 MMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDHRLERYSQQPGADFLCDIYQQDHL----- 311
            ...||: |.|.|.|         .|::.:.....:|..:||..::.....:...::|..|
  Fly   263 YFKTPL-LKKMLRT---------MDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLK 317

Mouse   312 -SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQRLLREIQSVLPDNQTPRAE-DVRNM 374
             .||.......::.:|.|:||:::...:|..|::||:.|.||..|:..|||:..:...| .::|:
  Fly   318 VDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNV 382

Mouse   375 PYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYTLPKGTVLTLNTQVLGSSEDNFEDADKFRPER 439
            |||:||:|||.|:.|.|....|.|.:.:|:..|.:|.||::::.......||:.|....:|.|||
  Fly   383 PYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPER 447

Mouse   440 WLEKE------------KKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIIQKYNIVATDSEP 492
            ||...            |..|||..||||.|.|||:|:|:.|::|.|....:|:.:|:....|..
  Fly   448 WLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTK 512

Mouse   493 VEMLHLGILVPSRELPIAF 511
            .......|.:|:  :|:.|
  Fly   513 NAFRSALINLPN--IPLKF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp24a1	NP_034126.1	p450	59..513	CDD:278495	129/500 (26%)
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	124/463 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770