DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp24a1 and shd

DIOPT Version :9

Sequence 1:	NP_034126.1	Gene:	Cyp24a1 / 13081	MGIID:	88593	Length:	514	Species:	Mus musculus
Sequence 2:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	142/559 - (25%)
Similarity:	244/559 - (43%)	Gaps:	84/559 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 CPIDKRRPLIAFLRRL-----------RDLGQPPRSVTSKAHVKRAPKEVPLCPLMTDGETRNVT 56
            |.:.:.:....:||.|           .:|.||           .|||.          ..|.:.
  Fly    17 CALHRHKLADIYLRPLLKNTLLEDFYHAELIQP-----------EAPKR----------RRRGIW 60

Mouse    57 SLPGPTNWPLLGS---LLEIFWKGGLKKQHDTLAEYHKKYGQI-FRMKLGSFDSVHLGSPSLLEA 117
            .:|||...|.||:   .|..|.:..:.|.|:..|:.:::||.| ..:...:...|||.:...||.
  Fly    61 DIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLEVMPSNVPIVHLYNRDDLEK 125

Mouse   118 LYRTESAHPQRLEIKPWKAYRDHRNEAY---GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKI 179
            :.:..|.:|.|...:....||..|.:.|   |::..:|..|||:||:....:..|..:......:
  Fly   126 VLKYPSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPAL 190

Mouse   180 NEVLADFMGQIDELRDERGRIQDLYSEL-NKWSFESICLVLYEKRFGLLQKDTE--EEALTFIAA 241
            |.|..||:..:...||....:...:.|| |....|::|.::..:|.|.|..||:  ::.....||
  Fly   191 NAVCDDFIELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQKISQLAAA 255

Mouse   242 IKTMM-----STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDHRLERYSQQPGAD- 300
            :|.:.     |.:|      :.|.|...||.::....|.|.|:..:...|||.||...:....:
  Fly   256 VKQLFISQRDSYYG------LGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACED 314

Mouse   301 ---------FLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQRLLREI 356
                     || :|.:...|..::..:|:.:...|.:||.||:|:::|.:::.:|....|:|.|.
  Fly   315 DEAAGLRSIFL-NILELKDLDIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEF 378

Mouse   357 -----QSVLPDNQTPRAEDVRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYTLPKGTVLT 416
                 .::|.|..|       |..|.|||::||.||.|:.....|.|::...|..|:|..|||:.
  Fly   379 CEYRDTNILQDALT-------NATYTKACIQESYRLRPTAFCLARILEEDMELSGYSLNAGTVVL 436

Mouse   417 LNTQVLGSSEDNFEDADKFRPERWLEKEKK------INPFAHLPFGVGKRMCIGRRLAELQLHLA 475
            ....:....:.||:.|.:|.||||::...:      .|....:|||||:|.|.|:|..|:::.|.
  Fly   437 CQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLL 501

Mouse   476 LCWIIQKYNIVATDSEPVEMLHLGILVPSRELPIAFCPR 514
            |..::..:::  :..:|:|.....:|.|...|.:....|
  Fly   502 LAKMVLAFDV--SFVKPLETEFEFLLAPKTPLSLRLSDR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp24a1	NP_034126.1	p450	59..513	CDD:278495	130/489 (27%)
shd	NP_001261843.1	p450	63..528	CDD:299894	128/480 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.770