DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp24a1 and Cyp12d1-p

DIOPT Version :9

Sequence 1:	NP_034126.1	Gene:	Cyp24a1 / 13081	MGIID:	88593	Length:	514	Species:	Mus musculus
Sequence 2:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	136/522 - (26%)
Similarity:	252/522 - (48%)	Gaps:	62/522 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 RSVTSKAHVKRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEY- 89
            ||.:..|| ::|...:      |: |.:....:|.|..:    ..:..|..|| :.|:.::.||
  Fly    21 RSASVLAH-EQAKSSI------TE-EHKTYDEIPRPNKF----KFMRAFMPGG-EFQNASITEYT 72

Mouse    90 ---HKKYGQIFRM--KLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDH-RNEAY--- 145
               .|:||.|:.|  ..|..|.|...:...:|.::|.|...|:|..:.....:|:| |.:.|
  Fly    73 SAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEV 137

Mouse   146 -GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFMGQIDELRDERGR--IQDLYSEL 207
             ||:..:.:.|.::|||.....|:|..:....:.::.:..:|:.:|.|:||.:..  .:|...|:
  Fly   138 QGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEI 202

Mouse   208 NKWSFESICLVLYEKRFGLLQKDTE-EEALTFIAAIKTMMS-TF--------GKMMVTPV--ELH 260
            ::..|||:.||.::::.||::|:.: .:|||.....:.:.. ||        .|::.||.  ::.
  Fly   203 SRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMK 267

Mouse   261 KRLNTKVWQAHTLAWDTIFKSVKPCIDHRL---ERYSQQPGADFLCDIYQQDHLSKKELYAAVTE 322
            :.||..:..|..:     .|..:..::.|.   |:.:.....:.|.:|      ..|.......:
  Fly   268 RTLNDSLNVAQKM-----LKENQDALEKRRQAGEKINSNSMLERLMEI------DPKVAVIMSLD 321

Mouse   323 LQLAAVETTANSLMWILYNLSRNPQVQQRLLREIQSVLPDNQT-PRAEDVRNMPYLKACLKESMR 386
            :..|.|:.||..|..:|..||::|..|.:|..|:.|::|...: ...|::::||||:|.:||::|
  Fly   322 ILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLR 386

Mouse   387 LTPSVPFTTRTLDKPTVLGEYTLPKGTVLTLNTQVLGSSEDNFEDADKFRPERWLE-----KEKK 446
            ..|:...|.||.....:|..|.:||||.:.|.:.||......:...|:|.|||||.     |:.:
  Fly   387 YYPNGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQ 451

Mouse   447 INPFAHLPFGVGKRMCIGRRLAELQLHLALCWIIQKYNIV--ATDSEPVEMLHLGILVPSRELPI 509
            ::||..||||.|.|||||:|:.:|::...:..:|:.:::.  ...|.|.:.:.  ::.|:...|.
  Fly   452 VSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPFKTMF--VMEPAITFPF 514

Mouse   510 AF 511
            .|
  Fly   515 KF 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp24a1	NP_034126.1	p450	59..513	CDD:278495	129/489 (26%)
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	120/450 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870