DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1a1 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_001129531.1	Gene:	Cyp1a1 / 13076	MGIID:	88588	Length:	524	Species:	Mus musculus
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	147/523 - (28%)
Similarity:	227/523 - (43%)	Gaps:	78/523 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 VFCLGFWVVRATRT-----WVPKGLKTPPGPWGLPFIGHMLTVGK-------------------- 61
            :|....|:..||..     .|.|..:.||||...|.:|..|.|.:
  Fly     1 MFYTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYV 65

Mouse    62 NPHLSLTRLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGKSMT 126
            ||:       ..||    ::||...||:....:.|.:.:.  .:|..||||...:.|.|....:.
  Fly    66 NPY-------GFYG----LKIGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRLRTFNSRLG 117

Mouse   127 FNPDSGPVWAARRRLAQNALKSFSIASDPTSASSCYLEEHVSKEANYLVSKLQ-KVMAEVG---H 187
            .....|.:|..:||.....||:|..|...       :.:.|..||..|:..|: ||:...|   .
  Fly   118 VLLTDGEMWVEQRRFILRHLKNFGFARSG-------MMDIVHNEATCLLQDLKDKVLKSGGKQTR 175

Mouse   188 FDPYKYLVVSVANVICAICFGQRYDHDDQELLSIVNLSNE-FGEVTGSGYPADFIPVLRYL-PN- 249
            .:.:....|.|.|.:..:..|:||:....|:..::....| |..:...|......|:||:: ||
  Fly   176 IEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNF 240

Mouse   250 SSLDAFKDLNDKFYSFMKKLIKEH---YRTFEKGHIRDITDSLIEHCQDRKLDENANVQLSDDKV 311
            |..:.|.:.:...|:||.|.|:.|   |:.:::.  ||:.||.: ..||...||..  ..||..:
  Fly   241 SGYNGFVESHRSLYTFMSKEIELHRLTYKNYDEP--RDLMDSYL-RAQDEGNDEKG--MFSDQSL 300

Mouse   312 ITIVLDLFGAGFDTVTTAISWSLMYLVTNPRVQRKIQEELDTVIGRDRQPRLS-DRPQLPYLEAF 375
            :.|.||:|.||.:|...::.:..|:||..|.:|.:..:|:..|:|.:|.|..| ||.:|||.||.
  Fly   301 LAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAI 365

Mouse   376 ILETFRHSSFVPFTIPHSTTRDTSLNGFYIPKGCCV-------FVNQWQVNHDRELWGDPNEFRP 433
            .||..|......|.|||....||.|:|:.|||...|       .:|...       :.||..|.|
  Fly   366 TLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVD-------FPDPESFNP 423

Mouse   434 ERFLTPSGTLDKRLSEKVTLFGLGKRKCIGETIGRSEVFLFLAILLQQIEFKVSPGEKVDMTPTY 498
            :|:|. .|.|  :|.|....||.|:.:|:|:.:||..:|:|...:||..:....||:..:..|..
  Fly   424 DRYLF-DGHL--KLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLE 485

Mouse   499 GLT 501
            |.|
  Fly   486 GAT 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1a1	NP_001129531.1	Mitochondrial targeting signal. /evidence=ECO:0000250\|UniProtKB:P00185	33..44		3/15 (20%)
Cyp1a1	NP_001129531.1	p450	44..503	CDD:365848	141/496 (28%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	138/486 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920