Protein Alignment Cyp19a1 and Cyp4c3

DIOPT Version :9

• Sequence 1: NP_001335100.1
• Gene: Cyp19a1 / 13075
• MGIID: 88587
• Length: 503
• Species: Mus musculus
• Sequence 2: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 119/559 - (21%)
• Similarity: 241/559 - (43%)
• Gaps: 104/559 - (18%)

Mouse    13 VTIMVPETVTVSAM--------PL-LLIMG---LLLLIWNCESS------SSIPGPGYCLGIGPL 59
            :|.::.|::.:|.:        |: :.::|   :.|:::|...|      ..||||.....:|..
  Fly     6 ITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNA 70

Mouse    60 I----SHGRFLWMGIGSACNYYNKMYGE---FMRVWISGEETLIISKSSSMFHVMKHSHYISRFG 117
            |    .|.......||     ..|::|.   ..|||......:::.:..::..::....::::
  Fly    71 IEMNVDHDELFNRVIG-----MQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNK-- 128

Mouse   118 SKRGLQCIGMHE---------NGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEV-----CVESI 168
                     .|:         .|::.:.:.. |.:.|.....|.....|...::|     .|.:.
  Fly   129 ---------SHDYDYLHPWLGEGLLTSTDRK-WHSRRKILTPAFHFKILDDFIDVFNEQSAVLAR 183

Mouse   169 KQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPL-----DESAIVKKIQGYFNAWQA-- 226
            |..::...|..:...||.:.||  .|:.:|:    :|..:     .||..||.:.|..:..|:
  Fly   184 KLAVEVGSEAFNLFPYVTLCTL--DIVCETA----MGRRIYAQSNSESEYVKAVYGIGSIVQSRQ 242

Mouse   227 --LLIKPNIFFKISWLYRKYERSVKDL-----------KDEIAVLVEKKRHKVSTAEKLED---- 274
              :.::.:..|.::..|:.::..:..|           |.|:|:|.|...:..:.|....|
  Fly   243 AKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGK 307

Mouse   275 --CMDFATDLIFAERRGD-LTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEI 336
              .:.|...||.|.:.|. |:.|::.:.:...:....||.|..:.:.|.|:..:||.:..:::|:
  Fly   308 KKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEEL 372

Mouse   337 HTVVGD---RDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNI 398
            .::.||   ....::::.:::.:|..|.:|:|..|.|.::.|...||..|.|..|..||..|:..
  Fly   373 DSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMT 437

Mouse   399 GRMHR-LEYFPKPNEFTLENF-EKNV----PYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRR 457
            ..:|| ...||||.:|..:|| .:|.    |:.|. ||..|||.|.|:..|::..|.|:.|:||:
  Fly   438 YALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYI-PFSAGPRNCIGQKFAILEEKAVISTVLRK 501

Mouse   458 FQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRN 496
            ::::.:.:|  |::....:|.|.|.:.   :.:..:||:
  Fly   502 YKIEAVDRR--EDLTLLGELILRPKDG---LRVKITPRD 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	108/496 (22%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	108/500 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950