DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp19a1 and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	125/524 - (23%)
Similarity:	213/524 - (40%)	Gaps:	129/524 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 MPLLLIMG--LLLLIWN---------CESSSSIPGPGYCLGIGPLISHG-RFLWMG----IGSAC 74
            |.|.||.|  :|||.|:         ....|:||||   :.| |::..| :.|.:|    ||...
  Fly     1 MWLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGP---ISI-PILGCGLQALHLGAENIIGWVG 61

Mouse    75 NYYNKMYGEFMRVWISGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQCIGMHE-------NGI 132
            ..::| ||:..|.||.| |:||.:|....|..:..|..:...|.        ::|       :|:
  Fly    62 EKFDK-YGKTFRFWILG-ESLIYTKDLQYFETILSSTTLLEKGQ--------LYEYLRPFLNDGL 116

Mouse   133 IFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQH----LDRLGEVTDTSGYVDVLTLMRH 193
            :.:.... |...|..|..|..    .:::|..||.:.:|    :|.|.:|.|....||:|..:..
  Fly   117 LVSTGRK-WHARRKIFTHAFH----FKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSL 176

Mouse   194 IMLDTSNMLFLGIPLD-----ESAIVKKIQGYFNAWQALLIKPNIFFKIS----WLYRKYERSV- 248
            ..||......:|:.::     :...:|.::      ..:.|:|:..|:.|    ||:......:
  Fly   177 AALDVITEAAMGVQVNAQNDPDFPYIKALK------SVVYIQPDRMFRFSRRYNWLFPLAAPLLH 235

Mouse   249 KDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERR-----------------GD------ 290
            :.|..:|.|:     |            || ||.:.:|||                 ||
  Fly   236 RQLLSDIRVM-----H------------DF-TDKVISERRETVRRAKADGTYRPLSLGDAEIGSK 282

Mouse   291 ------------------LTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIH 337
                              |:..::.:.:...:....||.|..:...|..:|.:|||:..|.:|:.
  Fly   283 SQMALLDILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQ 347

Mouse   338 TVVG---DRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIG 399
            .|:|   ...:....:|:||.::..|.|:||..|.|..:.|.|.::..|....:...|:|.|.:.
  Fly   348 RVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLY 412

Mouse   400 RMHR-LEYFPKPNEFTLENFEKNVPYRY----FQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQ 459
            ..|| ..|||.|..|..|.|.::....:    :.||..||:.|.|:..|::.|||::..:||.::
  Fly   413 YAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYE 477

Mouse   460 VKTL 463
            :..|
  Fly   478 LLPL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	114/491 (23%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	114/491 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845270
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950