Protein Alignment Cyp19a1 and Cyp4aa1

DIOPT Version :9

• Sequence 1: NP_001335100.1
• Gene: Cyp19a1 / 13075
• MGIID: 88587
• Length: 503
• Species: Mus musculus
• Sequence 2: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 116/523 - (22%)
• Similarity: 220/523 - (42%)
• Gaps: 113/523 - (21%)

Mouse     1 MFLEMLNPMQYNVTIMVPETVTVSAMPLLLIMGL---------------LLLIWNCESSSSIPGP 50
            ||:|.:.....|:.:        .::.:||::.|               :||........|:|..
  Fly     1 MFVEKVLERTTNLEL--------CSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFL 57

Mouse    51 GYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWI---------SGEETLIISKSSSMFHV 106
            |.|:    |::....:....|.|.:    :||..:|:|:         ..|:..:|..|.
  Fly    58 GNCM----LVTDKDLMRRCAGKAFD----LYGSLVRIWVLLFPFFAVLEPEDLQVILSSK----- 109

Mouse   107 MKHSHYISRFGSKRGLQCIGMHE---NGIIFNNNPSLW----RTIRPFFMKALTGPGLVRMVEVC 164
             ||::.:..:..        ||.   :|:| .::.|.|    |.|:|.|...|    |.:.::..
  Fly   110 -KHTNKVFFYRL--------MHNFLGDGLI-TSSGSKWSNHRRLIQPAFHHNL----LEKFIDTF 160

Mouse   165 V---ESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPL----DESAIVK------- 215
            |   :|:.::||  .|...|.  :::...:.:.:||..|...||:|:    .:.|:::
  Fly   161 VDASQSLYENLD--AEAVGTE--INIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFRQG 221

Mouse   216 KIQGYFNAWQALLIKPNIFFKISW-------LYRKYERSVKDLKDEIAVLVEKKR--HKVSTAEK 271
            ||.......|..|:...|:   .|       |.:|     |.|.|....:::::|  ...:....
  Fly   222 KIMMPARFTQPWLLLDGIY---HWTKMANDELNQK-----KRLNDFTRKMIQRRRQIQNNNNGNS 278

Mouse   272 LEDC-MDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKE 335
            ...| :|...::  :|...|.|:|::.......::|..|::...:.|.|.|:.:.||.:...:.|
  Fly   279 ERKCLLDHMIEI--SESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLE 341

Mouse   336 IHTVVGD--RDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNI 398
            :.|:..|  |...:.|:..::.:|..|.|::|..|.|.|:.|:..|:..:..:.:..|:|:.:..
  Fly   342 LATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICP 406

Mouse   399 GRMHRLEY-FP-----KPNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRR 457
            ...|||.: :|     :|..|:.||.|...||. |.||..|||.|.|...|::.:|.::..|||.
  Fly   407 YATHRLAHIYPDPEKFQPERFSPENSENRHPYA-FLPFSAGPRYCIGNRFAIMEIKTIVSRLLRS 470

Mouse   458 FQV 460
            :|:
  Fly   471 YQL 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	106/461 (23%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	107/466 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950