DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp19a1 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	119/487 - (24%)
Similarity:	205/487 - (42%)	Gaps:	80/487 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    25 AMPLLLIMGL---------LLLIWNCESSSSIPGPGYCLGIGP------LIS----HGR---FLW 67
            |:||||:..|         :|..:|......:.|..:.:|..|      :.|    :|:   ..|
  Fly    10 ALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFVFW 74

Mouse    68 MGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQCIGMHENGI 132
            :|..|.....:..|.||    |...:|||   :.|..:.:.|             ..:|:   |:
  Fly    75 IGTYSNVLVTSSKYLEF----ILSSQTLI---TKSDIYQLTH-------------PWLGL---GL 116

Mouse   133 IFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLD 197
            : .:..|.|...|.....|.....|....||..|:..:.:..|..|.......|......::.||
  Fly   117 L-TSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLD 180

Mouse   198 TSNMLFLGIPLD-----ESAIVKKIQGY-----FNAWQALLIKPN-IFFKISWLYRKYERSVKDL 251
            ......:|:.::     .|:||:..:..     ..|:..|  |.| :.::::..|..|.|::|.|
  Fly   181 VICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPL--KRNELLYRLAPDYPAYSRTLKTL 243

Mouse   252 KDEIAVLVEKK--RHK---VST---AEKLEDCMDFATDLIFAERRG-DLTKENVNQCILEMLIAA 307
            :|....::.|:  .||   |||   .|.....|.|...|:.:...| .|..:.:.:.:...:...
  Fly   244 QDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEG 308

Mouse   308 PDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVGD----RDIKIEDIQNLKVVENFINESMRYQP 368
            .||.:..:.|.:.|::.:.:.:..:.||...|:|:    ||...::|..:|.::.||.|:.|..|
  Fly   309 HDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYP 373

Mouse   369 VVDLVMRRALEDDVIDGYPVKKGTNIILNIGRM---HRLEYFPKPNEFTLENF--EKNVPYRYFQ 428
            .|..:.|...:|.||||..|.|||.  ||:|.:   :..:.|..|::|..|.|  ||..|:.|.
  Fly   374 SVPFIGRFTEKDYVIDGDLVPKGTT--LNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFEYV- 435

Mouse   429 PFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQV 460
            ||..|||.|.|:..|::.:|.|:..::|.|:|
  Fly   436 PFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	111/455 (24%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	111/462 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.040