DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp19a1 and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	115/541 - (21%)
Similarity:	205/541 - (37%)	Gaps:	162/541 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 MPLLLIMGLLL--LIW---------NCESSSSIPGPGYCLGIGPLISHG-------------RFL 66
            |.:||.:.:|:  |:|         |....|.|.|| :.:   |::.:|             ||
  Fly     1 MWILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGP-FTI---PIVGNGLQALTLRPENFIQRF- 60

Mouse    67 WMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMFH-------VMKHSH---YISRFGSKRG 121
                   .:|:|| ||:..|:||.| |.||.:|....|.       ::|.:|   ::..|
  Fly    61 -------GDYFNK-YGKTFRLWILG-ECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDF----- 111

Mouse   122 LQCIGMHENGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVD 186
               :|   :|::.:.. :.|.:.|.....|.....|...||:...:....:::|....|....||
  Fly   112 ---LG---DGLLLSTG-NKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVD 169

Mouse   187 VLTLMRHIMLDTSNMLFLGIPLD-------------------ESAIVKKIQGYFNAWQALLIKPN 232
            :...:....||.:....:|:.::                   ||..:..:...:| |...|..|.
  Fly   170 LFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYN-WLFPLAAPL 233

Mouse   233 IFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERRGDLTKENVN 297
            :       ||:       |:.:||::                 .|| ||.:..|||..|.:...:
  Fly   234 V-------YRR-------LQKDIAIM-----------------QDF-TDKVIRERRAILERARAD 266

Mouse   298 ------------------QCILEMLI-----------------------AAPDTMSVTLYFMLLL 321
                              ..:|::|:                       |..||.:..:...|..
  Fly   267 GTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHA 331

Mouse   322 VAEYPEVEAAILKEIHTVVG---DRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVI 383
            ::.:|:|:..|.:|:.:|:|   |..:....:..||.::..|.|:||..|.|.::.|...||..|
  Fly   332 ISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI 396

Mouse   384 DGYPVKKGTNIILNIGRMHR-LEYFPKPNEFTLENF-----EKNVPYRYFQPFGFGPRGCAGKYI 442
            ....:...|:|:|....::| .||||.|..|..|.:     ..|.|...:.||..||:.|.|:..
  Fly   397 GEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKF 461

Mouse   443 AMVMMKVVLVTLLRRFQVKTL 463
            |.:.||.::..::|.:::..|
  Fly   462 ANLQMKALISKVIRHYELLPL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	106/508 (21%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	105/505 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940