Protein Alignment Cyp19a1 and Cyp4ac2

DIOPT Version :10

• Sequence 1: NP_031836.1
• Gene: Cyp19a1 / 13075
• MGIID: 88587
• Length: 503
• Species: Mus musculus
• Sequence 2: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 489
• Identity: 112/489 - (22%)
• Similarity: 205/489 - (41%)
• Gaps: 73/489 - (14%)

Mouse    64 RFLWMGIG------SACNYYNKMYGEFM--RVWISGEET-------LIISKSSSMFHVM------ 107
            |.||..:.      |.|.......|..:  :::::..:|       |:...|.|:|:.|
  Fly    17 RKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESIFNFMRDASAK 81

Mouse   108 -KHSHYISRFGSKRGLQCIGMHENGIIFNNNP-----SLWRTIRPFF---------------MKA 151
             |..:|:..|........:...|...|..::.     .::..::||.               .||
  Fly    82 AKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKWHSRRKA 146

Mouse   152 LTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNML---FLGIPLDESA- 212
            ||.....::::..:...|:..::|.:|...|..:: |.|.:.|...|.|.:   .||:.||:.:
  Fly   147 LTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME-LELNQVIPQFTLNNVCETALGVKLDDLSE 210

Mouse   213 ---IVKKIQGYFNAWQALLIKPNIFFKISW--LYRKYERSVKDLK--DEIAVLVEKKRHKVSTAE 270
               ..:.|.......|..|..| .|:.|.:  |:..|.:.|.:||  .|.:..:.:||..:..:.
  Fly   211 GIRYRQSIHAIEEVMQQRLCNP-FFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSN 274

Mouse   271 KLEDCMDFA--------TDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPE 327
            :|....:|.        ..|:.||..|.:..:.:...:...:....||.|..|.|.||::|.:.:
  Fly   275 QLGQEDEFGKKQRYAMLDTLLAAEADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHED 339

Mouse   328 VEAAILKEIHTVVGDR-DIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKG 391
            |:....:||..:..|. ||.:.....|..:|..|.||:|..|.|..:.||.:|:.|::|..:.|.
  Fly   340 VQKKCYEEIKYLPDDSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVVNGLIMPKN 404

Mouse   392 TNIILNIGRMHR-LEYF--PK---PNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVV 450
            |.|.:::..:.| ..:|  ||   |:.|..||.....|:. |.||..|.|.|.|:..|::.:||:
  Fly   405 TQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFA-FVPFSAGQRNCIGQKFAILEIKVL 468

Mouse   451 LVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNED 484
            |..::|.|  |.|....::::..:|.:.|...::
  Fly   469 LAAVIRNF--KILPVTLLDDLTFENGIVLRTKQN 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_031836.1	CYP19A1	72..485	CDD:410709	109/475 (23%)
Cyp4ac2	NP_608917.3	CYP4	84..503	CDD:410721	99/422 (23%)