DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp19a1 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	113/504 - (22%)
Similarity:	208/504 - (41%)	Gaps:	107/504 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    44 SSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKM---YGEFMRVWISGEETLIISKSSSMFH 105
            :.::|||    .||.||::     :..|...|:..::   :|...|:|...:..::.:....:..
  Fly    32 AKTLPGP----TIGELIAN-----VKKGEILNWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQ 87

Mouse   106 VMKHSHYISRFGSKRGLQ-CIGMHENGIIFNNNPSLWRTIRPFFMKALTGPG-----LVRMVEVC 164
            ::.::..:::..:...|: .:|   .|::.|...| |...|    |.|| ||     |....|..
  Fly    88 LLGNNQLLTKSRNYELLEPWLG---KGLLTNGGES-WHRRR----KLLT-PGFHFRILSEFKEPM 143

Mouse   165 VESIKQHLDRL-----GEVTDTSGYVDVLTL----------MRHIMLDTSNMLFLGIPLDESAIV 214
            .|:.:..:.||     ||..|...|:.:..|          .:|..|.:           :|..|
  Fly   144 EENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKHAQLQS-----------DSEYV 197

Mouse   215 KKIQGY--------FNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEK 271
            :.:|..        |:.||.|    |:|||.:...::.|.::|.|.||...::..:|.:: ..|:
  Fly   198 QAVQSICRVMHKQSFSFWQRL----NVFFKHTKPGKEREAALKVLHDETNRVIRLRREQL-IQER 257

Mouse   272 LEDCMDFATDLIFAERR---------------GDLTKENVNQCILEMLIAAPDTMSVTLYFMLLL 321
            .|...:...|.:.|:||               .:|:..::.:.:...:....||.|..:.|.|.|
  Fly   258 NEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSL 322

Mouse   322 VAEYPEVEAAILKEIHTVVGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGY 386
            :::.|:|:....:|...:.|      .:.:::..:|..|.|::|..|.|....|:.|||..:...
  Fly   323 LSKNPDVQQRAFEEASELEG------REKESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKL 381

Mouse   387 PVKKGTNIILNIGRMHR-LEYFPKPNEFTLENF---EKNVPYRYFQPFGFGPRGCAGKYIAMVMM 447
            .|.||.:|...|..:|| .:.||.|..|..:.|   ||.:....|..|..|||.|.|:..||:.:
  Fly   382 TVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKFAMLEL 446

Mouse   448 KVVLVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRN 496
            |..|..|||.::.          :|.|:      ::.:.|.|::....|
  Fly   447 KTSLAMLLRSYRF----------LPDKD------HQPKPLAELVTKSGN 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	110/490 (22%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	110/489 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950