DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp19a1 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	132/537 - (24%)
Similarity:	223/537 - (41%)	Gaps:	131/537 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 TVTVSAMPLL-LIMGLLLLI-----WNCESS-----SSIPGPGYCLGIGPL-----ISHGRFLWM 68
            |..:...|:| .::|.|:.:     |...|.     ::||.|.....:|..     :|:...|.:
  Fly    19 TTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAV 83

Mouse    69 GIGSACNYYNKMYGEFMRVWIS----------GEETLIISKSSSMFHVMKHSHYISRFGSKRGLQ 123
            |:|    |.|| |||.|:.|:.          .:..||:|....:....::.::...||
  Fly    84 GLG----YLNK-YGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFG------ 137

Mouse   124 CIGMHENGIIFNNNPSLWR----TIRPFFMKALTGPGLVRMVEVCVESIKQHLDRL----GEVTD 180
                  :|::.:|... ||    .|.|.|.:::    |...|...|:..|..:.|:    |:..|
  Fly   138 ------DGLLISNGHH-WRHHRKMIAPTFHQSI----LKSFVPTFVDHSKAVVARMGLEAGKSFD 191

Mouse   181 TSGYVDVLTLMRHIMLDTSNMLFLGIP---------------LDESAIVKKIQGYFNAWQALLIK 230
            ...|:...|:  .|:|.|:    :|:.               :|...|:.|.|      ..||.:
  Fly   192 VHDYMSQTTV--DILLSTA----MGVKKLPEGNKSFEYAQAVVDMCDIIHKRQ------VKLLYR 244

Mouse   231 PNIFFKISWLYRKYERS-----------VKDLK----DEIAVLVEKKRHKVST--AEKLEDCMDF 278
            .:..:|.:.|..|.:|.           |||.|    :|...:||:....|::  |.|.|...|.
  Fly   245 LDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDD 309

Mouse   279 ATDL----IFAERRGDL---------------TKENVNQCILEMLIAAPDTMSVTLYFMLLLVAE 324
            ..|:    :.|:||..|               .::::...:..::....||.|....|.|.::..
  Fly   310 LDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGI 374

Mouse   325 YPEVEAAILKEIHTVVGD---RDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDD--VID 384
            :.:::|.:..|...:.||   ||....|...:|.:|..|.|::|..|.|.|:.|| |:.|  :..
  Fly   375 HKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARR-LDYDLKLAS 438

Mouse   385 G-YPVKKGTNIILNIGRMHRL-EYFPKPNEFTLENF--EK--NVPYRYFQPFGFGPRGCAGKYIA 443
            | |.|.|||.:|:....:||. :.:|.|.:|..:||  |:  |..|..|.||..|||.|.|:..|
  Fly   439 GPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYA 503

Mouse   444 MVMMKVVLVTLLRRFQV 460
            |:.:||:|.|::|.:.|
  Fly   504 MLKLKVLLSTIVRNYIV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	124/498 (25%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	123/494 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110