DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp11b2 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_034121.4	Gene:	Cyp11b2 / 13072	MGIID:	88584	Length:	500	Species:	Mus musculus
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	114/508 - (22%)
Similarity:	210/508 - (41%)	Gaps:	92/508 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 LGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHS--VGKT 86
            ||.|..|.|       .|.||:.:...|:..:|.::               .|.|.|..  :|:.
  Fly    84 LGNTWRLMP-------IIGQYTISDVAKISSLLHDR---------------YGRIVRFGGLIGRP 126

Mouse    87 QIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHRELRGLRR-------GVFLLNGPEWRLNRLRL 144
            .::.:...::.||.::.|...|.|..:...|.::.:  :|:       ||..::|..||..|.|:
  Fly   127 DLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSV--VRKDFFGDLGGVVGVHGEPWREFRSRV 189

Mouse   145 NRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNARGSLTMDVQQSLFNYTIEASNFALFGERL 209
            .:.||....:::::..::::..|||...:..:.:|.  .|..|....:..:::|.........||
  Fly   190 QKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDENQ--ELPEDFDNEIHKWSLECIGRVALDTRL 252

Mouse   210 GLLGHDLSPGS--LKFIHALHSMFKSTSQLLFLPKSLTRWTSTRVWKEHFDAWDVISEYANRCIW 272
            |.|..:|.|.|  .:.|.|.....::.: .|.|.....|:..|.:|..:....:.......:.|.
  Fly   253 GCLESNLKPDSEPQQIIDAAKYALRNVA-TLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQ 316

Mouse   273 KVHQELRLGSSQTYSG----IVAELISQGSLPLDAIKANSMELTAGSVDTTAIPLVMTLFELARN 333
            ...:.|:.......:|    :...::||....:..|.|  ::|....:||.::.:...|::||..
  Fly   317 SATERLKTQDPSLRAGEPSLVEKVILSQKDEKIATIMA--LDLILVGIDTISMAVCSMLYQLATR 379

Mouse   334 PDVQKALRQESLAAEASIAANPQKAMSDLPL------LRAALKETLRLYP--VGGFLERILSSDL 390
            |..|:.:.:|.    ..:..:|...:: :||      |:..:||..|:|.  :|.  .|.|..|.
  Fly   380 PVDQQKVHEEL----KRLLPDPNTPLT-IPLLDQMHHLKGFIKEVFRMYSTVIGN--GRTLMEDS 437

Mouse   391 VLQNYHVPAGTLVLLYLYSMGRNPAVFP-----RPERYM-------PQRWLE--------RKRSF 435
            |:..|.||.|.            .||||     ..|.|:       |:|||:        :...|
  Fly   438 VICGYQVPKGV------------QAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPF 490

Mouse   436 QHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQVETLRQEDVQMAYRFVLMP 488
            ..|.:|:|.|.|||||.|::||.:||..:|:.:::| ...:.:..|..|:..|
  Fly   491 ASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLE-YNHKPLDYAVTFMYAP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp11b2	NP_034121.4	p450	42..496	CDD:365848	108/490 (22%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	111/494 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920