DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp11a1 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_062753.3	Gene:	Cyp11a1 / 13070	MGIID:	88582	Length:	526	Species:	Mus musculus
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	135/554 - (24%)
Similarity:	224/554 - (40%)	Gaps:	85/554 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 VKGCQPFLSPTWQGPVLSTGKGAGTST----------SSPR-----------SFNEIPSPG---- 52
            ::.|.|.:|..............|.:|          |:||           .:|:||.|.
  Fly    19 LRQCVPRISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPI 83

Mouse    53 -DNGW--LNLYHFWRESGTQKIH--YHQMQSFQKYGPIYR--EKLGTLESVYIVDPKDASILFSC 110
             .|.|  :.:...:..|...||.  .|     .:||.|.|  ..:|..:.::|.|..:....:..
  Fly    84 LGNTWRLMPIIGQYTISDVAKISSLLH-----DRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRS 143

Mouse   111 EGPNPERFLVPPWVAYHQYYQRPI-----GVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEG 170
            |||.|.|..:|..|.|....::..     ||:....:.|::.|..:.:.|:....|:.::..||.
  Fly   144 EGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEV 208

Mouse   171 VAQDFIKVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEIVDP--EAQRFINA 233
            :.:||: |....:..:|. .......:::.::|.|.|..|....|:|.||..:.|  |.|:.|:|
  Fly   209 ITEDFL-VRCENLLDENQ-ELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDA 271

Mouse   234 V-YQMFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPGV 297
            . |.:  .:|..|.|...::|...|..|..:....:.......:|.|:     ..:|..:|.|
  Fly   272 AKYAL--RNVATLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQS-----ATERLKTQDP-- 327

Mouse   298 LYSLLGGN-KLPFKNIQANITEMLAG---------GVDTTSMTLQWNLYEMAHNLKVQEMLRAEV 352
              ||..|. .|..|.|.:...|.:|.         |:||.||.:...||::|.....|:.:..|:
  Fly   328 --SLRAGEPSLVEKVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEEL 390

Mouse   353 LAARRQAQGDMAKMVQLVPL------LKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLV 411
               :|........:.  :||      ||..|||..|::...:...|..:.|.|:..|::|.....
  Fly   391 ---KRLLPDPNTPLT--IPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQA 450

Mouse   412 QVASFAMGRDPGFFPNPNKFDPTRWLEKSQNTT----H-FRYLGFGWGVRQCLGRRIAELEMTIL 471
            ...:...|....:..:...|.|.|||:.....|    | |..|.:|:|.|.|||||.|:|||.||
  Fly   451 VFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQIL 515

Mouse   472 LINLLENFRIEVQNLRDVGTKFSLILMPENPILF 505
            |..||.|:::| .|.:.:....:.:..|:.|:.|
  Fly   516 LAKLLRNYKLE-YNHKPLDYAVTFMYAPDGPLRF 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49		6/39 (15%)
Cyp11a1	NP_062753.3	p450	49..507	CDD:278495	125/497 (25%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	122/477 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870