Protein Alignment Cyp11a1 and Cyp12d1-p

DIOPT Version :10

• Sequence 1: NP_062753.3
• Gene: Cyp11a1 / 13070
• MGIID: 88582
• Length: 526
• Species: Mus musculus
• Sequence 2: NP_610635.4
• Gene: Cyp12d1-p / 246648
• FlyBaseID: FBgn0050489
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 137/558 - (24%)
• Similarity: 234/558 - (41%)
• Gaps: 104/558 - (18%)

Mouse     7 SLRSVLVKGCQPFLSPTWQGPVLSTGKGA--------GTSTSSPRSFNEIPSPGDNGWLNLYHFW 63
            |.|||.:          :.|||.|:...:        .:.|...::::|||.|      |.:.|.
  Fly     6 SARSVAI----------YVGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRP------NKFKFM 54

Mouse    64 R------ESGTQKIHYHQMQSFQKYGPIY--REKLGTLESVYIVDPKDASILFSCEGPNPERFLV 120
            |      |.....|..:.....::||.||  ....|..:.|...:.||..::|..||..|.|..:
  Fly    55 RAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGL 119

Mouse   121 PPWVAYHQYYQRP------IGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVL 179
            .. :.|.:.:.||      .|::...::||.|.|..:|...|.|..::.:...|..:..:||:
  Fly   120 DS-IVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIE-- 181

Mouse   180 HRRIKQQNSGNFSGV---ISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQRFINAVYQMFHTS 241
              |||:........|   .:|::.|..|||:..|.|..:||::.:      .|..:....:|.||
  Fly   182 --RIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRK------NRDNSDALTLFQTS 238

Mouse   242 VPM------LNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPGVLYS 300
            ..:      |::.|..::::.|.|::......:...|.|.:..:.....|.::|.
  Fly   239 RDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQ---------- 293

Mouse   301 LLGGNKLPFKNIQANITE------------MLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVL 353
              .|.|:...::...:.|            :|..|||.|:..|...|..::.:...|..||.|:|
  Fly   294 --AGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELL 356

Mouse   354 A--------ARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTL 410
            :        ...:...||       |.|:|.||||||.:|..:...|...||::|..|::|..|.
  Fly   357 SIMPTKDSLLNEENMKDM-------PYLRAVIKETLRYYPNGLGTMRTCQNDVILSGYRVPKGTT 414

Mouse   411 VQVASFAMGRDPGFFPNPNKFDPTRWLE-----KSQNTTHFRYLGFGWGVRQCLGRRIAELEMTI 470
            |.:.|..:.::..::|.|::|.|.|||.     |....:.|.:|.||:|.|.|:|:|:.:|||..
  Fly   415 VLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMET 479

Mouse   471 LLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQ 508
            .:..|:.||.:|..  ||....|..:.:.|..|.|.|:
  Fly   480 TVAKLIRNFHVEFN--RDASRPFKTMFVMEPAITFPFK 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..49		3/26 (12%)
		cytochrome_P450	79..504	CDD:477761	116/466 (25%)
Cyp12d1-p	NP_610635.4	CYP24A1-like	76..508	CDD:410677	115/463 (25%)