DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp11a1 and Cyp12d1-p

DIOPT Version :9

Sequence 1:	NP_062753.3	Gene:	Cyp11a1 / 13070	MGIID:	88582	Length:	526	Species:	Mus musculus
Sequence 2:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	137/558 - (24%)
Similarity:	234/558 - (41%)	Gaps:	104/558 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 SLRSVLVKGCQPFLSPTWQGPVLSTGKGA--------GTSTSSPRSFNEIPSPGDNGWLNLYHFW 63
            |.|||.:          :.|||.|:...:        .:.|...::::|||.|      |.:.|.
  Fly     6 SARSVAI----------YVGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRP------NKFKFM 54

Mouse    64 R------ESGTQKIHYHQMQSFQKYGPIY--REKLGTLESVYIVDPKDASILFSCEGPNPERFLV 120
            |      |.....|..:.....::||.||  ....|..:.|...:.||..::|..||..|.|..:
  Fly    55 RAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGL 119

Mouse   121 PPWVAYHQYYQRP------IGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVL 179
            .. :.|.:.:.||      .|::...::||.|.|..:|...|.|..::.:...|..:..:||:
  Fly   120 DS-IVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIE-- 181

Mouse   180 HRRIKQQNSGNFSGV---ISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQRFINAVYQMFHTS 241
              |||:........|   .:|::.|..|||:..|.|..:||::.:      .|..:....:|.||
  Fly   182 --RIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRK------NRDNSDALTLFQTS 238

Mouse   242 VPM------LNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPGVLYS 300
            ..:      |::.|..::::.|.|::......:...|.|.:..:.....|.::|.
  Fly   239 RDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQ---------- 293

Mouse   301 LLGGNKLPFKNIQANITE------------MLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVL 353
              .|.|:...::...:.|            :|..|||.|:..|...|..::.:...|..||.|:|
  Fly   294 --AGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELL 356

Mouse   354 A--------ARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTL 410
            :        ...:...||       |.|:|.||||||.:|..:...|...||::|..|::|..|.
  Fly   357 SIMPTKDSLLNEENMKDM-------PYLRAVIKETLRYYPNGLGTMRTCQNDVILSGYRVPKGTT 414

Mouse   411 VQVASFAMGRDPGFFPNPNKFDPTRWLE-----KSQNTTHFRYLGFGWGVRQCLGRRIAELEMTI 470
            |.:.|..:.::..::|.|::|.|.|||.     |....:.|.:|.||:|.|.|:|:|:.:|||..
  Fly   415 VLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMET 479

Mouse   471 LLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQ 508
            .:..|:.||.:|..  ||....|..:.:.|..|.|.|:
  Fly   480 TVAKLIRNFHVEFN--RDASRPFKTMFVMEPAITFPFK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49		3/26 (12%)
Cyp11a1	NP_062753.3	p450	49..507	CDD:278495	125/505 (25%)
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	115/469 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870