Protein Alignment Cybb and Duox

DIOPT Version :9

• Sequence 1: NP_031833.3
• Gene: Cybb / 13058
• MGIID: 88574
• Length: 570
• Species: Mus musculus
• Sequence 2: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 153/584 - (26%)
• Similarity: 265/584 - (45%)
• Gaps: 100/584 - (17%)

Mouse    11 SIFVILVWLGLNVFLFINYYKVYDDGPKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNL 75
            :||.:.::..:.:.||:..:..|....::...|.::|..:|:.|..||.|:|...|:||.:.|||
  Fly  1029 NIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNL 1093

Mouse    76 LSFLRGSSACCSTRIRR--QLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGISDRYS 138
            ::.|:      ...|::  .||.::.|||:.|......:.:||:.|:.|.             |.
  Fly  1094 ITKLK------EFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNF-------------YH 1139

Mouse   139 IALSDIGDNENEEYL----NFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRR 199
            ::..   .:||...|    :||.:...:....|:..||   |.||:::.:.:.:|...:..|||:
  Fly  1140 VSTQ---SHENLRCLTREVHFASDYKPDITFWLFQTVT---GTTGVMLFIIMCIIFVFAHPTIRK 1198

Mouse   200 SYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLEEHNLDICADKIEEWGKIKECPVPKFAG 264
            ..:..||..|.|::..::...|||..|:.
  Fly  1199 KAYNFFWNMHTLYIGLYLLSLIHGLARLT------------------------------------ 1227

Mouse   265 NPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQM-KKKGFKMEVGQYIFVK 328
            .||..|.:.:||..:|..:::|........:.:......|...|:::. :....|...||::.:.
  Fly  1228 GPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLS 1292

Mouse   329 CPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWT---EGLFNACGCDKQEFQDAWKLPKIAVDGP 390
            |......|.|.|||||||.|:|.|.||:..|.||   ...|:.|..:.::      .|||.::||
  Fly  1293 CTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPED------QPKIRIEGP 1351

Mouse   391 FGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATS-LKLKKIYFYWLCRDTHAFEWF 454
            ||..::|.:.:||.::||.||||||:||||..:.:....|..| :..||:||.|:|.....||||
  Fly  1352 FGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWF 1416

Mouse   455 ADLLQLLETQMQERNNANFLSYNIYLTGWDES----------QANHFAVHHDEEKDVITGLKQKT 509
            .|:|:    .:::::..|.|..:|::|.:...          ..|||  ....:..:.||||...
  Fly  1417 IDVLR----DVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHF--QRLSKTSIFTGLKAVN 1475

Mouse   510 LYGRPNWDNEFKTIASEHPNTT-IGVFLCGPEALAETLSK--QSISNSESGPRGVHFIFNKENF 570
            .:|||:..:..|.:..:|...: ||||.|||..|.:::..  ..::.:...|   :||.:.|||
  Fly  1476 HFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTRKLP---YFIHHFENF 1536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cybb	NP_031833.3	Ferric_reduct	66..219	CDD:366815	38/158 (24%)
		PLN02844	<165..>423	CDD:215453	72/261 (28%)
		NOX_Duox_like_FAD_NADP	297..570	CDD:99783	89/290 (31%)
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	38/157 (24%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	89/285 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710