Protein Alignment ACVR1C and daf-1

DIOPT Version :9

• Sequence 1: NP_660302.2
• Gene: ACVR1C / 130399
• HGNCID: 18123
• Length: 493
• Species: Homo sapiens
• Sequence 2: NP_001023159.1
• Gene: daf-1 / 176829
• WormBaseID: WBGene00000897
• Length: 669
• Species: Caenorhabditis elegans
• Alignment Length: 537
• Identity: 187/537 - (34%)
• Similarity: 267/537 - (49%)
• Gaps: 107/537 - (19%)

Human    39 TCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVT-KTE----------------- 85
            ||.|:|:|:.|...:             ||: :...|....:|| :||
 Worm    89 TCYTDGSCYQSARPS-------------PEI-SHFGCMDEKSVTDETEFHDTAAKVCTNNTKDPH 139

Human    86 -----CCFT-DFCNNIT-LHLPTASPNAPKLGPMELA--IIITVP-----VCLLSIAAMLTVWAC 136
                 ||.. :||.|.| :||      ||  ||.:.:  :|:|:.     :.||.||..||..:.
 Worm   140 ATVWICCDKGNFCANETIIHL------AP--GPQQSSTWLILTILALLTFIVLLGIAIFLTRKSW 196

Human   137 QGRQCSY-RKKKRPNVEEPLSECN----LVNAG-------------------------------- 164
            :.:...| |.|.:|.  :||.|..    :|..|
 Worm   197 EAKFDWYIRFKPKPG--DPLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGI 259

Human   165 --KTLKDLIYDV--TASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFS 225
              ..:||:: ||  ..||||.|...|.:.||...|.|...||.||||.|..|.:.||.||||:|:
 Worm   260 MPNNMKDML-DVLEETSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFN 323

Human   226 SRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 290
            :.||.::.:|.||::|.||||.|:|.:|.:|..|.|..|:||||:|||..|||:|:|..|.|.:.
 Worm   324 ALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIE 388

Human   291 GMIKLALSIASGLAHLHMEIVGTQ--GKPAIAHRDIKSKNILVKKCETCAIADLGLAV-KHDSIL 352
            ....|..|.|||||.||.:|.|::  .|||:||||||||||:||...||||.||||:: |.:...
 Worm   389 TYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAA 453

Human   353 NTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQ-- 415
            :.|...:|.|.||.||:|||:|:.||...:|||::.||:||..||.||...||..|.::....
 Worm   454 SDIIANENYKCGTVRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAAT 518

Human   416 -LPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIK 479
             :||.:....||...:|..|||.::.||:....|:....::.:..|::.||..|.:||.|:...:
 Worm   519 VIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICR 583

Human   480 KTI---SQLCVKEDCKA 493
            |.:   .||.:.:..||
 Worm   584 KRMDERQQLLLDKKAKA 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1C	NP_660302.2	Activin_recp	26..100	CDD:279413	20/85 (24%)
		TGF_beta_GS	166..193	CDD:285687	12/28 (43%)
		Pkinase_Tyr	195..478	CDD:285015	128/288 (44%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	128/295 (43%)
daf-1	NP_001023159.1	GS	265..293	CDD:197743	12/28 (43%)
		Pkinase_Tyr	293..576	CDD:285015	125/282 (44%)
		STKc_TGFbR_I	297..589	CDD:270958	127/291 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451956
Domainoid	1	1.000	236	1.000	Domainoid score	I1477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I2302
Isobase	1	0.950	-	0	Normalized mean entropy	S3517
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm16226
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5155
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870