DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ctsd and cathD

DIOPT Version :9

Sequence 1:	NP_034113.1	Gene:	Ctsd / 13033	MGIID:	88562	Length:	410	Species:	Mus musculus
Sequence 2:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	219/410 - (53%)
Similarity:	279/410 - (68%)	Gaps:	30/410 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 VLLLILGLLASS--------SFAIIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPK 62
            |.||::..||::        ...::|:||.||.|.||...:||..::.|.:     :|.....|
  Fly     4 VALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHFADVGTELQQLRI-----RYGGGDVP- 62

Mouse    63 TTEPVSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDK 127
              ||:|    ||:||||||.|.||:|||.|.||||||||||||||..|.:.:|||.:|:||::.|
  Fly    63 --EPLS----NYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASK 121

Mouse   128 SSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAK 192
            |.||.||||.|.|.|||||||||||.||||:         .|:.::.|.|.||..:||:||||||
  Fly   122 SKTYTKNGTEFAIQYGSGSLSGYLSTDTVSI---------AGLDIKDQTFAEALSEPGLVFVAAK 177

Mouse   193 FDGILGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGEL 257
            ||||||:||..|||:.|.|.|..:.:|.|:...:|||||||||....|||::.||:|..:|.||.
  Fly   178 FDGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEF 242

Mouse   258 SYLNVTRKAYWQVHMDQLEVGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGE 322
            :||.||||||||:.||...:| :|.||||||:.|.||||||:..|:||...:.:.||..|:|.|:
  Fly   243 TYLPVTRKAYWQIKMDAASIG-DLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQ 306

Mouse   323 YMIPCEKVSSLPTVYLKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPLWILGDVF 387
            |::.|:.:..||.:...||||.:||....|||:|:|.|||||||||||:|||||:||||||||||
  Fly   307 YVVSCDLIPQLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVF 371

Mouse   388 IGSYYTVFDRDNNRVGFANA 407
            ||.|||.||..|:|||||:|
  Fly   372 IGKYYTEFDMGNDRVGFADA 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctsd	NP_034113.1	A1_Propeptide	21..46	CDD:285240	10/24 (42%)
		Cathepsin_D2	73..405	CDD:133157	195/331 (59%)
		Asp	78..407	CDD:278455	193/328 (59%)
cathD	NP_001334713.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836975
Domainoid	1	1.000	406	1.000	Domainoid score	I711
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55616
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1696
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm42823
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	LDO	PTHR47966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3883
SonicParanoid	1	1.000	-	-		X163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800