DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctcf and CTCF

DIOPT Version :9

Sequence 1:	XP_030099140.1	Gene:	Ctcf / 13018	MGIID:	109447	Length:	745	Species:	Mus musculus
Sequence 2:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	233/815 - (28%)
Similarity:	341/815 - (41%)	Gaps:	166/815 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 EESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQMVMMEQLDPTLLQMKT 84
            |:.:||:     ..:.:..||..:|..                ||:.::.:..|.:|  |.:...
  Fly    12 EDLQTFL-----NNFHKEIEGNSDEKV----------------VNTILEAISAEAID--LDENGA 53

Mouse    85 EVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPVPVTVPVATTSVEELQGAYEN 149
            |........||||.:|..:       ..||:..:..:...:.......:.......:|||...:.
  Fly    54 EAGGSKPMEEAEADLDHAE-------EAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQ 111

Mouse   150 EVSKEGL------------------AESEPMICHTLPLPEGFQVVKVGANGEVETLEQGELPPQE 196
            ..:|.|.                  |:|.|....:.|.||...:....|.......:|..:||
  Fly   112 AAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPP-- 174

Mouse   197 DSSWQKDPDYQPPAKKTK------KTKKSKLRYTEEGKDV-----------DVS----------- 233
                       |||...|      :.:|:.:....|..|:           |:|
  Fly   175 -----------PPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTV 228

Mouse   234 ------------------VYDFEEEQQEGLLSEVNAEK-----VVGN----MKPPKPTKIKKKGV 271
                              ||:||:   .....:.||:|     |:.|    :|....|.......
  Fly   229 DEAAVEAATATLTPNEAEVYEFED---NATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNAS 290

Mouse   272 KKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDC 336
            ...:.|..|.||..::..:.||.:||..|...||.:|.|:||:...|:||:|||.|.:||||..|
  Fly   291 GHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLC 355

Mouse   337 DMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTY 401
            :.||.||||||||.|||||.|||.||:.|.|||||::||:||:..||||||:||..|:|||:|.:
  Fly   356 ESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMF 420

Mouse   402 KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLR 466
            ||||||..|:|||.|:|.||.:|||||.::|.|.|.....:...|.|.:|.|...||:||.||::
  Fly   421 KLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIK 485

Mouse   467 KQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKP 531
            ..|: .:....||.|.....:||....|.|||:.||.:.|..|.||...:||:..|...|..|||
  Fly   486 HMHT-SDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKP 549

Mouse   532 YACSHCDKTFRQKQLLDMHFKRYHDPNFVP-----AAFVCSKCGKTFTRRNTMARHADNCAGPDG 591
            :.|..|.:.|||:|||..|....|:..:.|     ....|..|.:.||.:..:.||
  Fly   550 FHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRH--------- 605

Mouse   592 VEGENGGETKKSKRGR---KRKMRSKKEDS-----SDSEENAEPDLDDNEEEEEP----AVEIEP 644
            :|..:.....:.||.|   .|.:|.:|:.:     .|...:.:.|.::|||::.|    ..||||
  Fly   606 METHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEP 670

Mouse   645 EPEPQPQ---------PPPPPQPVAPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIE 700
            |......         ..|..|.:.|||....|:      ......:.||..|.|......|
  Fly   671 ENSEAEDADDDVETIVSDPIRQRIKPAPIIINKQ------ARLAASEKQPMIINQRLRSQRG--- 726

Mouse   701 NIIVEVKKEPDAE--PAEGEEEEAQAATTDAPNGD 733
            .....:|:|||..  ..|.:.::.:....:..|||
  Fly   727 TKTFHIKEEPDNSDFTVEWQGDDGEVMVVELVNGD 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctcf	XP_030099140.1	zf-H2C2_5	275..298	CDD:372805	7/22 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		zf-H2C2_2	289..314	CDD:372612	10/24 (42%)
		C2H2 Zn finger	305..325	CDD:275368	9/19 (47%)
		zf-H2C2_2	318..342	CDD:372612	14/23 (61%)
		C2H2 Zn finger	333..356	CDD:275368	16/22 (73%)
		zf-H2C2_5	360..384	CDD:372805	13/23 (57%)
		C2H2 Zn finger	362..382	CDD:275368	11/19 (58%)
		COG5048	<375..509	CDD:227381	61/133 (46%)
		C2H2 Zn finger	390..410	CDD:275368	12/19 (63%)
		C2H2 Zn finger	418..435	CDD:275368	9/16 (56%)
		C2H2 Zn finger	448..466	CDD:275368	9/17 (53%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	518..543	CDD:372612	9/24 (38%)
		C2H2 Zn finger	534..555	CDD:275368	9/20 (45%)
		C2H2 Zn finger	566..582	CDD:275368	4/15 (27%)
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	18/102 (18%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	136/309 (44%)
		zf-C2H2	322..344	CDD:278523	10/21 (48%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		zf-H2C2_2	337..361	CDD:290200	14/23 (61%)
		C2H2 Zn finger	352..373	CDD:275368	14/20 (70%)
		C2H2 Zn finger	381..401	CDD:275368	11/19 (58%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	12/19 (63%)
		zf-H2C2_2	422..446	CDD:290200	15/23 (65%)
		C2H2 Zn finger	437..457	CDD:275368	11/19 (58%)
		C2H2 Zn finger	467..485	CDD:275368	9/17 (53%)
		C2H2 Zn finger	496..516	CDD:275370	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	9/20 (45%)
		zf-C2H2	587..609	CDD:278523	7/30 (23%)
		C2H2 Zn finger	589..609	CDD:275368	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAC7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2480
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42355
orthoMCL	1	0.900	-	-		OOG6_107263
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.750