DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vcan and lectin-22C

DIOPT Version :9

Sequence 1:	NP_001074718.1	Gene:	Vcan / 13003	MGIID:	102889	Length:	3354	Species:	Mus musculus
Sequence 2:	NP_001137766.1	Gene:	lectin-22C / 7354375	FlyBaseID:	FBgn0259230	Length:	263	Species:	Drosophila melanogaster

Alignment Length:	157	Identity:	40/157 - (25%)
Similarity:	65/157 - (41%)	Gaps:	25/157 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse  3106 TFRCLCLPSYVGAL----CEQDTETCDYGWHKFQGQCYKYF--AHRRTWDAAERECRLQGAHLTS 3164
            |.|..|:...:.||    .|..|:....|:.:. |..|.|.  ...:.|..|.:.||..|.||..
  Fly   110 TERLNCMEGILSALEKTVLEVKTKIKYLGFEQI-GSKYYYIEKVSEKNWSTASKTCRNMGGHLAD 173

Mouse  3165 ILSHEEQMFV--NRVGHDYQWIGLNDKMFEHDFRWTD---GSALQYENW---RPNQPDSFFSAGE 3221
            |....:...:  |.....:.|:|:||  .:|:.::..   |....:..|   ||:|.|:.
  Fly   174 IKDEADLAAIKANLKEDTHYWLGIND--LDHEGKFLSMPTGKQTTFLKWASGRPSQLDTL----- 231

Mouse  3222 DCVVIIWHENGQWNDVPCNYHLTYTCK 3248
            :||.:.   ||:..|.||:|...:.|:
  Fly   232 NCVFLY---NGEMYDYPCHYTFRFICQ 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vcan	NP_001074718.1	IG_like	29..147	CDD:214653
		Ig_Versican	36..151	CDD:143309
		Link_domain_CSPGs_modules_1_3	150..244	CDD:239594
		Link_domain_CSPGs_modules_2_4	251..346	CDD:239597
		GAG-alpha (glucosaminoglycan attachment domain)	348..1308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..646
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..863
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	881..908
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1010..1088
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1252..1288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1524
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1924..1963
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2471..2490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2849..2904
		EGF_CA	3049..3083	CDD:238011
		EGF_CA	3085..3121	CDD:238011	5/18 (28%)
		CLECT_CSPGs	3127..3250	CDD:153058	33/132 (25%)
		CCP	3254..3310	CDD:153056
lectin-22C	NP_001137766.1	CLECT	146..255	CDD:153057	30/118 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4956
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940