DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csf3r and Dscam1

DIOPT Version :9

Sequence 1:	NP_031808.2	Gene:	Csf3r / 12986	MGIID:	1339755	Length:	837	Species:	Mus musculus
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	865	Identity:	164/865 - (18%)
Similarity:	294/865 - (33%)	Gaps:	259/865 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    35 VVRLGDPVLASCTISPNCSKLDQQAKILWRLQD-------EPIQPGDRQHHLPDGTQESLITLPH 92
            ::.:||.:...|.|    .|.|:..|:.|..:.       :.:||..|.:.:.:.|  |:|::
  Fly   632 LINMGDSIDLFCQI----QKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKT--SMISI-- 688

Mouse    93 LNYTQAFLFCLVPWEDSVQLLDQAELHAGYPPASPSNLSCLMHLTTNSLVCQWEPGPETH----- 152
                                          |.|||:      |...::.:...:.|..|:
  Fly   689 ------------------------------PSASPA------HTGRDTCIASNKAGTTTYSVDLT 717

Mouse   153 --LPTSFIL----KSFRSRADCQYQ-----------------GDTIPDCVAKKRQNNCSIPRKNL 194
              :|..:||    |:|...:|.:.:                 |||..:....|:.:|..:....|
  Fly   718 VNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTL 782

Mouse   195 LLYQ--------YMAIWVQAENMLGSSESPKLCLD----PMDVVKL--------EPPMLQALDIG 239
            .:..        |:.   :|.|.:||..|..:.:.    |....||        ||.:||.
  Fly   783 HVDNIQKTNEGYYLC---EAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQC---- 840

Mouse   240 PDVVSHQP-GCLW----LSWKPWKPSEYMEQECELRYQPQLKGANWTLVFHLPSSKDQFELCGLH 299
             :....:| |.||    :...|...:.|     .:|.:....|...:|........|
  Fly   841 -EAKGEKPIGILWNMNNMRLDPKNDNRY-----TIREEILSTGVMSSLSIKRTERSD-------- 891

Mouse   300 QAPVYTLQMRCIRSSLPGFWSPWSPGLQLRPTMKAPTIRLDTWCQKKQLDPGTVSVQLFW-KP-- 361
             :.::|    |:.::..|. ...|..:.::...:.|       ...|.||....||||.| :|
  Fly   892 -SALFT----CVATNAFGS-DDASINMIVQEVPEMP-------YALKVLDKSGRSVQLSWAQPYD 943

Mouse   362 --TPLQEDSGQIQGYLLSWSS------PDHQGQDIHLCNTTQLSCIFLLPSEAQNVTLVAYNKAG 418
              :||.....:.:....|||.      |.|         ||:.....|.|:...|:.:||.|..|
  Fly   944 GNSPLDRYIIEFKRSRASWSEIDRVIVPGH---------TTEAQVQKLSPATTYNIRIVAENAIG 999

Mouse   419 T--SSPTTVVFLENEGPAVTGLHAMAQDLN--TIWVDWEAPSLLPQ--------GYLIEWEMSSP 471
            |  ||....:....|.|:....:...:.:|  |:.|.|:.|   |:        ||.:.:::|
  Fly  1000 TSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPP---PRTEWNGEILGYYVGYKLS-- 1059

Mouse   472 SYNNSYKSWMIEPNGNIT-----GILLKDNINPFQLYRITVAPLYPGIVGP-PVNVYTFAGERAP 530
               |:..|::.|....||     ..|...|:..:..|.:.:........|| ......|..|..|
  Fly  1060 ---NTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTP 1121

Mouse   531 PHAPALHLKHVGTTWA----QLEWVPEAPRL----GMIPLTHYTIF-----WADAGDHSFSVTLN 582
            ...|:   ....||..    ::.||  :|.|    |:|. |:..::     |.|.....:..|.:
  Fly  1122 SQPPS---DTACTTLTSQTIRVGWV--SPPLESANGVIK-TYKVVYAPSDEWYDETKRHYKKTAS 1180

Mouse   583 ISLHDFVLKHLEPASLYHVYLMATSRAG-STNSTGLTLRTLDPSDLNIFLGILCLVLLSTTCVVT 646
               .|.||..|:..:.|.:.::||:..| ...|..:..:| :|........:..||:.:...:|:
  Fly  1181 ---SDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQT-EPDVPEAPTDVKALVMGNAAILVS 1241

Mouse   647 WLCCKRRGKTSFWSDVPDPAHSSLSSWLPTIMTE--------ETFQLPSFWDSSVPSITKITELE 703
            |             ..|...:..::.:  |:.::        :|.::|.:..|     .:.||||
  Fly  1242 W-------------RPPAQPNGIITQY--TVYSKAEGAETETKTQKVPHYQMS-----FEATELE 1286

Mouse   704 EDKKPTHWDSESS--GNGSLPALVQAYVLQGDPREISNQSQPPSRTGDQVLYGQVLESPTSPGVM 766
            ::|....|.:.|:  |.|.....:.|......|.:|::.....:.|
  Fly  1287 KNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTAT------------------- 1332

Mouse   767 QYIRSDSTQPLLGGPTPSPK 786
              .:.|:..|.|....|.|:
  Fly  1333 --FKEDAKMPCLAVGAPQPE 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csf3r	NP_031808.2	Lep_receptor_Ig	24..111	CDD:399379	14/82 (17%)
		FN3	123..221	CDD:419708	25/133 (19%)
		WSXWS motif	319..323		0/3 (0%)
		FN3	354..426	CDD:238020	25/84 (30%)
		FN3	433..524	CDD:238020	20/106 (19%)
		FN3	530..611	CDD:214495	22/94 (23%)
		Box 1 motif	658..666		1/7 (14%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165	19/116 (16%)
		IGc2	735..804	CDD:197706	10/71 (14%)
		I-set	819..914	CDD:254352	21/118 (18%)
		Ig	833..921	CDD:299845	18/111 (16%)
		FN3	918..1011	CDD:238020	29/108 (27%)
		FN3	1018..1116	CDD:238020	19/105 (18%)
		FN3	1124..1217	CDD:238020	22/101 (22%)
		FN3	1222..1312	CDD:238020	18/109 (17%)
		Ig	1339..1406	CDD:299845	4/12 (33%)
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910