DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM45 and TIF35

DIOPT Version :9

Sequence 1:	XP_016858809.1	Gene:	RBM45 / 129831	HGNCID:	24468	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_010717.1	Gene:	TIF35 / 852039	SGDID:	S000002837	Length:	274	Species:	Saccharomyces cerevisiae

Alignment Length:	187	Identity:	42/187 - (22%)
Similarity:	79/187 - (42%)	Gaps:	25/187 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   174 APRERTRQPRPPGDRTAVAGLPLSLALTNPPALEFTAKLVLAYFEYFSDLPLSDAQISIYKKRK- 237
            |..||.::.:....:|   ||...|...:...:....|.:|:......|...::..:....:.|
Yeast    90 AEEERIQKEKASLTKT---GLQCRLCGNDHMTMNCPFKTILSELSALEDPATNEGGVEAASEEKA 151

Human   238 -----NSTFPQVFIAQSR-------SSGSHRD--VEDEELTRIFVMIPKSYTEEDLREKFKV-YG 287
                 ..:.|..::..||       ||.::||  ..|:..|...:.:.::..|..|||:... :.
Yeast   152 GQVGGAGSIPGQYVPPSRRAGARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLREELLFPFA 216

Human   288 DIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCD-RSFRAIL-----AEPKNK 338
            .|...|:::||.||:|:||.:|.:.....|.||:...| |.:..::     ::||.|
Yeast   217 PIPRVSVVRNKETGKSRGLAFVTFSSEEVAEQALRFLDGRGYMNLILRVEWSKPKVK 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM45	XP_016858809.1	RRM1_RBM45	23..101	CDD:409801
		PABP-1234	<41..206	CDD:130689	7/31 (23%)
		RRM2_RBM45	263..336	CDD:409802	20/79 (25%)
		RRM3_RBM45	389..461	CDD:409803
		RRM4_RBM45	534..601	CDD:409804
TIF35	NP_010717.1	eIF3g	6..127	CDD:403535	8/39 (21%)
TIF35	NP_010717.1	RRM_eIF3G_like	192..268	CDD:409842	20/75 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910