Protein Alignment DIS3L2 and SSD1

DIOPT Version :10

• Sequence 1: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Sequence 2: NP_010579.1
• Gene: SSD1 / 851887
• SGDID: S000002701
• Length: 1250
• Species: Saccharomyces cerevisiae
• Alignment Length: 853
• Identity: 237/853 - (27%)
• Similarity: 384/853 - (45%)
• Gaps: 129/853 - (15%)

Human    37 SKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG--DRDIFIDGV 99
            |:..:..|.:||:|..|:.:.::.|.::.|.|:.|:||:|.|...:|:: |.||  |.||:|.|.
Yeast   328 SQGNNNGGGRKSLFAPYLPQANIPELIQEGRLVAGILRVNKKNRSDAWV-STDGALDADIYICGS 391

Human   100 VARNRALNGDLVVVKLL-PEEHWKVVK-PESNDKETEAAYESDIPEELCGHHLPQQSLKSY-ND- 160
            ..|||||.||||.|:|| .::.|:..| .|...:..:|:.:.|:        :|..|...| ||
Yeast   392 KDRNRALEGDLVAVELLVVDDVWESKKEKEEKKRRKDASMQHDL--------IPLNSSDDYHNDA 448

Human   161 ------------SP---------DVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGRED 204
                        ||         |:.|..:...:.:.|...:: :....||::.|   |.|.|
Yeast   449 SVTAATSNNFLSSPSSSDSLSKDDLSVRRKRSSTINNDSDSLS-SPTKSGVRRRS---SLKQR-- 507

Human   205 GDAPVTK--DETTCISQDTRALSEKSLQRSAK------VVYILEKKHSRAATGFLKLL------- 254
               |..|  |:.....|....:.|:.:....|      ||.:|::...:..:|.|.||
Yeast   508 ---PTQKKNDDVEVEGQSLLLVEEEEINDKYKPLYAGHVVAVLDRIPGQLFSGTLGLLRPSQQAN 569

Human   255 ADKNS-ELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQ 318
            :|.|. ....|.|.|.|:|.:||.|.:|.:..|:|||.....|:..||:..|..|........|.
Yeast   570 SDNNKPPQSPKIAWFKPTDKKVPLIAIPTELAPKDFVENADKYSEKLFVASIKRWPITSLHPFGI 634

Human   319 LAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLEC------LPQGLPWTIPPEEFSKRR---DL 374
            |...||...:.:.|.:.||.    |.:..|:|.|:.      .|...|..:..|....||   |.
Yeast   635 LVSELGDIHDPDTEIDSILR----DNNFLSNEYLDQKNPQKEKPSFQPLPLTAESLEYRRNFTDT 695

Human   375 RKDCIFTIDPSTARDL----DDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVY 435
            .:..||.|.     :|    :.||..:...:|..::|.|:.||:..:.|||.:|:.|.:|:::|:
Yeast   696 NEYNIFAIS-----ELGWVSEFALHVRNNGNGTLELGCHVVDVTSHIEEGSSVDRRARKRSSAVF 755

Human   436 LVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEG-KILDEWFGRTIIRSCTKLSYEHAQS 499
            :.||:|.:||:...:|| ||.|..:..|.||::||.... :|...|.|.:.|.....||.|....
Yeast   756 MPQKLVNLLPQSFNDEL-SLAPGKESATLSVVYTLDSSTLRIKSTWVGESTISPSNILSLEQLDE 819

Human   500 MIE--SPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVD-GALRLDQLKLAFTLD 561
            .:.  |||..:.                     .:..||:....:|..| .|..|..|.|..:||
Yeast   820 KLSTGSPTSYLS---------------------TVQEIARSFYARRINDPEATLLPTLSLLESLD 863

Human   562 HETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLVEFCD 626
            .|. :....:|.:......::.|.....|..||.||:....:.|||||...|....::...:...
Yeast   864 DEK-VKVDLNILDRTLGFVVINEIKRKVNSTVAEKIYTKLGDLALLRRQMQPIATKMASFRKKIQ 927

Human   627 QMGLPVDFSSAGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMALYFCSGLLQDPAQFRHYAL 691
            ..|...|.::|..|.|.:.:...||.     :..:..:..:.|..|.||.:|.: ||.|:.||||
Yeast   928 NFGYNFDTNTADELIKGVLKIKDDDV-----RVGIEILLFKTMPRARYFIAGKV-DPDQYGHYAL 986

Human   692 NVPLYTHFTSPIRRFADVLVHRLLAAAL---GYRERLDMAPDTLQKQADHCNDRRMASKRVQELS 753
            |:|:|||||:|:||:||.:|||.|.|.:   .|.|  ||  :.|:..:::||.::..:.:.||.:
Yeast   987 NLPIYTHFTAPMRRYADHVVHRQLKAVIHDTPYTE--DM--EALKITSEYCNFKKDCAYQAQEQA 1047

Human   754 TSLFFAVLVKE----SGPLESEAMVMGILKQAFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKP 814
            ..|.....:.:    :|.|.:.|.|:.:.:.:|||.:..:|::||::.:.|.|....|.  |...
Yeast  1048 IHLLLCKTINDMGNTTGQLLTMATVLQVYESSFDVFIPEFGIEKRVHGDQLPLIKAEFD--GTNR 1110

Human   815 ELTLVWEP 822
            .|.|.|:|
Yeast  1111 VLELHWQP 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		1/7 (14%)
		Rrp44_CSD1	50..238	CDD:375054	60/222 (27%)
		VacB	231..745	CDD:440323	155/547 (28%)
		Dis3l2_C_term	766..855	CDD:465547	18/57 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885
SSD1	NP_010579.1	OB_Dis3	582..657	CDD:436091	25/78 (32%)
		RNB	689..1014	CDD:459934	106/358 (30%)
		Dis3l2_C_term	1064..1151	CDD:465547	18/57 (32%)