Protein Alignment DIS3L2 and dis3l2

DIOPT Version :10

• Sequence 1: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Sequence 2: XP_031757683.1
• Gene: dis3l2 / 780265
• XenbaseID: XB-GENE-5958094
• Length: 1068
• Species: Xenopus tropicalis
• Alignment Length: 850
• Identity: 574/850 - (67%)
• Similarity: 679/850 - (79%)
• Gaps: 25/850 - (2%)

Human    20 SAVAGPHDIGASPGDKKS---KNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFH 81
            |....|...|...|..:|   ..:|.:|||||:||.||:||:||.|||||.||||.|||||||||
 Frog   238 SEFLSPVQSGTQRGTNRSILNNKKSGKGKKKSVFEAYMTKEEVSAGLKRGELIQGPLRINPKKFH 302

Human    82 EAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELC 146
            ||::|||||.||:||||||.||||||||:|||||||:|.|||:|   ||    ...:.|.|....
 Frog   303 EAYLPSPDGVRDLFIDGVVPRNRALNGDVVVVKLLPQEQWKVLK---ND----VCEDDDTPGHST 360

Human   147 G---HHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAP 208
            |   |.|....:||...:||:|:||:.| |.:||||   ::.|:.       |: :|..:|.|..
 Frog   361 GNKQHALSPHLMKSSAKNPDLIIEAKVD-SSAEDGH---ESALIG-------CL-QKEIKDQDKL 413

Human   209 VTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSPSDH 273
            ...:|.|....|.:..|:...|::||||||||||||||||||:|.|:||:|:|.||.|||||.||
 Frog   414 GAIEEKTSKQGDPKTFSDDCFQKTAKVVYILEKKHSRAATGFIKPLSDKSSDLARKRALFSPVDH 478

Human   274 RVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILT 338
            |:|||||||.|||.||...|:.||||||||.|..|::|.|||.|:|.|||||||||||||||||.
 Frog   479 RLPRIYVPLGDCPHDFAIHPETYANTLFICSITAWRDDSNFAEGKLMKSLGQAGEIEPETEGILV 543

Human   339 EYGVDFSDFSSEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGN 403
            |||||||||..:||:||||.||||||.|||.||:|||.:|||||||:||||||||||||||.|||
 Frog   544 EYGVDFSDFPDKVLQCLPQDLPWTIPQEEFQKRKDLRNECIFTIDPATARDLDDALSCKPLPDGN 608

Human   404 FKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIW 468
            |:||||||||||||.|||.||.:|:||||||||||||:|||||||||||||||||:|:|||||||
 Frog   609 FEVGVHIADVSYFVAEGSALDIMASERATSVYLVQKVIPMLPRLLCEELCSLNPMTDRLTFSVIW 673

Human   469 TLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLH 533
            .:||:|:||||||||::|.||.||||:|||:||..|.:||...||||:||:|:..|:||||||||
 Frog   674 KITPQGEILDEWFGRSVICSCVKLSYDHAQNMINHPDKKIEQHELPPVSPQHTINEIHQAVLNLH 738

Human   534 GIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIH 598
            .||:.||:|||.|||||||||||.||||.|:||||||:||:||:||||||||||||||||||.|:
 Frog   739 LIAQNLRKQRFDDGALRLDQLKLTFTLDKESGLPQGCYIYQYRDSNKLVEEFMLLANMAVAHHIY 803

Human   599 RAFPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDFSSAGALNKSLTQTFGDDKYSLARKEVLTN 663
            |.|||:|||||||||||:||:||:||||||||.:||||:|.|:|||...|..|:||.||||||||
 Frog   804 RRFPEEALLRRHPPPQTKMLNDLIEFCDQMGLQLDFSSSGTLHKSLNDQFETDEYSAARKEVLTN 868

Human   664 MCSRPMQMALYFCSGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALGYRERLDMA 728
            |||||||||:|||:|.|:|...|.||||||||||||||||||||||:|||||||:||....|.|.
 Frog   869 MCSRPMQMAVYFCTGALKDETLFHHYALNVPLYTHFTSPIRRFADVIVHRLLAASLGCGPPLKMP 933

Human   729 PDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVKESGPLESEAMVMGILKQAFDVLVLRYGVQK 793
            .:.:||||||||||:.|||||||||..|||:|.|||.|||||||||||:|.:||||:|||:||||
 Frog   934 KEVIQKQADHCNDRKTASKRVQELSAELFFSVFVKECGPLESEAMVMGVLNEAFDVIVLRFGVQK 998

Human   794 RIYCNALALRSHHFQKVGKKPELTLVWEPEDMEQEPAQQVITIFSLVEVVLQAESTALKYSAILK 858
            |||||:|.|.:.|||:|||:|||||:||||...:||.:|||:||:||||||::::..|||:|:||
 Frog   999 RIYCNSLPLVNSHFQQVGKRPELTLLWEPEKKGEEPVRQVISIFTLVEVVLKSDNVPLKYTAVLK 1063

Human   859 RPGTQ 863
            .|..|
 Frog  1064 SPEAQ 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		6/27 (22%)
		Rrp44_CSD1	50..238	CDD:375054	95/190 (50%)
		VacB	231..745	CDD:440323	390/513 (76%)
		Dis3l2_C_term	766..855	CDD:465547	61/88 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885		1/3 (33%)
dis3l2	XP_031757683.1	Rrp44_CSD1	271..443	CDD:375054	95/190 (50%)
		VacB	438..947	CDD:440323	388/508 (76%)
		Dis3l2_C_term	971..1060	CDD:465547	61/88 (69%)